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The effect of botuline toxin A in the subscapular muscle in stroke patients with shoulder complaints; a randomized controlled trial.

We assume that relaxation of the subscapular muscle will lead to pain reduction and improvement of mobility in stroke patients with shoulder- or armpain and limited range of motion of the shoulder.

Microbiota composition in healthy termed infants consuming infant formulae with different fat blends.

Infant formulae with higher levels of milk fat result in improved microbiota composition as compared to standard formula.

OPEP Therapy in COPD/chronic bronchitis patients with excess mucus

The objective of this prospective randomised, double-blind, controlled trial is to evaluate the effect of OPEP use on respiratory symptoms in patients with COPD or chronic bronchitis with excessive mucus in daily clinical practice.

RELATE and PREDICT TRD.

1. Treatment resistant depression (TRD) is characterized by dopaminergic dysfunction as assessed with a fMRI Pavlovian learning task and [11C]Raclopride PET with amphetamine challenge; 2. Relative to placebo, current serotonergic and noradrenergic…

Treatment of bone loss and changes in bone architecture in osteopenic patients with Crohn's disease; a comparison between calcium supplementation and vitamin D alone or combined with oral Risedronate 35 mg once weekly.

Bifosfornates in combination with vitamin D and Calcium is more effective that Vitamin D and Calcium alone for Crohn’s disease related osteopenia.

BENEFIT study

Inhibition of TNF-alpha in IPF (idiopathic pulmonary fibrosis) will affect inflammatory and pro-fibrotic cytokine expression and thereby will slow-down disease progression in IPF

Multiple ascending dose study of ALKS 7119

Nitrate and muscle performance

We hypothesize that dietary nitrate supplementation improves muscle strength and muscle endurance performance.

Pulsed Electromagnetic Fields in the treatment of fresh scaphoid fractures. Clinical and radiological outcome. A multicentre, prospective, double-blind, placebo-controlled, randomized trial. (CMO nr 2009/196) (ABR nr NL27191.091.09).

The troublesome scaphoid fracture will heal faster and with less complications if bonegrowth stimulation through pulsed electromagnetic fields is applied directly.

Vitamin D suppletion and aspecific musculoskeletal disorders.

Vitamin D suppletion can relief aspecefic musculoskeletal disorders in allochtone patients.

Intradialytic protein ingestion and exercise study

- Intradialytic protein ingestion increases plasma total amino acid concentrations throughout hemodialysis compared to placebo. - Intradialytic exercise increases amino acid loss into the dialysate in fasted patients and decreases amino acid loss…

Cystic fibrosis; a hereditary inflammatory process.

N/A

Sumatriptan non-responders: evaluation of a possible biomarker.

Sumatriptan can block the increase in dermal blood flow (DBF) caused by application of capsaicin or electrical stimulation.

Assessment of Perinatal Outcome by uSe of Tocolysis in Early Labour: Nifedipine versus placebo in the treatment of preterm premature rupture of membranes.

The aim of the study is to assess whether in women with early PPROM tocolytics improve perinatal outcome.

Een studie naar de veiligheid en effecten van psychotherapie in combinatie met MDMA als behandeling voor zware post-traumatische stress stoornis

Global Growth hormone study in Adults with Prader-Willi Syndrome

Our hypothesis is that growth hormone threatment in adults with Prader-Willi Syndrome will improve their metabolic and cardiovascuar health, thereby resulting in a reduced mortality.

Feasibility and Safety of Inhaled Heparin in Intubated and Mechanically Ventilated Patients: A Randomized Controlled Trial Comparing Three Doses of Inhaled Unfractionated Heparin.

We hypothesize that unfractionated heparin could be of benefit in treatment of ALI. Delivering heparin directly to the pulmonary compartment may attenuate fibrin depositions more effectively while reducing the risk of bleeding as a result of…

Vasodilators in cold type Complex Regional Pain Syndrome.

Nitric oxide depending and independing vasodilation in patients with disused, cold type CRPS, will regenerate blood tissue distribution and consequently improve mobility and quality of life factors.

Low field TMS as depression treatment.

Low field TMS can reduce depression scores in treatment resistant patients.

A randomized, double blind, placebo-controlled, phase 2a study of the efficacy, safety and pharmacokinetics of MLN3897 in patients with rheumatoid arthritis taking methotrexate.

MLN3897 is safe and improves signs and symptoms of rheumatoid arthritis.