301 resultaten
We hypothesize that restoration of gut microbiota diversity (by using donor FMT enriched in Desulfovibrio strains) could have explicit beneficial effects on glucose metabolism and NAFLD (via improved fructose catabolism), which is driven by…
Supplementation with an over the counter multivitamin and mineral supplement (New Care Multi®) for 24 weeks in the winter and spring can prevent infections in patients with inflammatory bowel disease in remission with immunomodulators or biological…
Based on previous studies, we will expect that ambroxol improves neurological manifestations in patients with GD3.
We hypothesize that methylphenidate improves ADHD manifestations in adults with (late-diagnosed) PKU.
Perioperative magnesium infusion (maintaining a serum concentration between 1.5-2.0 mmol/L) is able to clinically significantly reduce the incidence of perioperative atrial fibrillation (POAF).
1. We hypothesize that the ingestion of 30 g of collagen peptides and 30 g of free amino acids (matching the profile of collagen peptides) will result in greater myofibrillar and connective tissue protein synthesis rates in skeletal muscle tissue at…
Let µT denote the mean value of the composite IBS-SSS score under treatment with the active / GOS and µP denote the mean value of the composite IBS-SSS score under placebo, then the primary two-sided hypothesis to be tested is: • H0: µT - µP = 0 (i.…
We expect better outcomes: ABC > CBM > sham-CBM
In this study we will investigate whether changes in gutmicrobiota composition induced by allogenic donor fecal transplantation (from longterm type 1 diabetes mellitus patients with preserved beta cell function) compared to placebo, , has…
We hypothesize that PHA-022121 will be more effective in both the treatment and prophylaxis of acute angioedema attacks in patients with acquired C1-inhibitor deficiency when compared to placebo.
Our research objectives are two-fold: First we investigate whether nocebo effects can be learned via electrical pain conditioning and verbal suggestions. We expect that participants in the nocebo group, but not the control group, will report higher…
We hypothesize that treatment with Tapentadol will reduce the development of chronic postoperative pain by enhancing or maintaining CPM responses and possibly reducing central sensitization. We hypothesize that a 4-week treatment with Tapentadol…
The primary objective is to investigate the effectiveness of a personalized 2-year multidomain lifestyle intervention on cognitive performance in older adults at risk of cognitive decline.
To reduce fatigue symptoms with the use of a bovine lactoferrin supplement in patients suffering from Long COVID.
The aim of this study is to prospectively assess the efficacy of LDN as induction therapy in CD.
Testosterone Therapy in (a)symptomatic, testosterone deficient men after Radical Prostatectomy improves functional and oncological outcome compared to testosterone deficient men who do not receive TRT.
We hypothesise that relapse of alcohol use will be reduced after two-weeks when participants participate in a AAT during an inpatient alcohol treatment compared to treatment as usual with a placebo AAT (sham training). We also assume that the effect…
Collagen supplementation will augment the increase in biomarkers of collagen synthesis compared to placebo in patients with osteoarthritis after total hip arthroplasty.
Rivastigmine will protect against the cognitive and memory side effects of ECT
We hypothesize that sympathetic activation of human BAT is mainly mediated by the ADRB2 rather than the ADRB3