22 resultaten
We hypothesize that restoration of gut microbiota diversity (by using donor FMT enriched in Desulfovibrio strains) could have explicit beneficial effects on glucose metabolism and NAFLD (via improved fructose catabolism), which is driven by…
We hypothesize that methylphenidate improves ADHD manifestations in adults with (late-diagnosed) PKU.
Perioperative magnesium infusion (maintaining a serum concentration between 1.5-2.0 mmol/L) is able to clinically significantly reduce the incidence of perioperative atrial fibrillation (POAF).
1. We hypothesize that the ingestion of 30 g of collagen peptides and 30 g of free amino acids (matching the profile of collagen peptides) will result in greater myofibrillar and connective tissue protein synthesis rates in skeletal muscle tissue at…
We expect better outcomes: ABC > CBM > sham-CBM
Supplementation with an over the counter multivitamin and mineral supplement (New Care Multi®) for 24 weeks in the winter and spring can prevent infections in patients with inflammatory bowel disease in remission with immunomodulators or biological…
1. There will be a significant improvement in cognitive control, attention bias and memory bias performance after completion of the selected training module in the active vs. control training. 2. Rumination and depressive symptom severity will…
As the pain quality item “unpleasantness” delineates EB pain, we hypothesize the modulation of affective pain processing in the brain by way of intervention with Transvamix (a CBM comprising THC and CBD) - objectified by functional magnetic…
We hypothesise that relapse of alcohol use will be reduced after two-weeks when participants participate in a AAT during an inpatient alcohol treatment compared to treatment as usual with a placebo AAT (sham training). We also assume that the effect…
We hypothesize that treatment with Sustained Release Calcium Butyrate (SRCaBu) will ameliorate: 1) the intestinal microbiome, intestinal barrier function and immune tolerance: 2) lower systemic inflammation of OA of the hand.
We hypothesis that collagen supplementation augments the benefits of jumping exercise for bone metabolism.
Collagen supplementation will augment the increase in biomarkers of collagen synthesis compared to placebo in patients with osteoarthritis after total hip arthroplasty.
We hypothesize that sympathetic activation of human BAT is mainly mediated by the ADRB2 rather than the ADRB3
Rationale: Loss of smell (anosmia) is common in COVID-19 infections. Most patients regain normal smell within 4 weeks, but in 6-8% the smell does not fully recovery. These persistent smell disorders greatly influence daily life. It is thought that…
Let µT denote the mean value of the composite IBS-SSS score under treatment with the active / GOS and µP denote the mean value of the composite IBS-SSS score under placebo, then the primary two-sided hypothesis to be tested is: • H0: µT - µP = 0 (i.…
Early IVIg treatment in addition to prednisone results in a meaningful clinical response in treatment naive myositis patients in the short term and increased HR-QoL in the long term
The null hypothesis states there is no difference in effectiveness of the ESPB compared to placebo on early postoperative pain intensity measured with NRS in patients that underwent lumbar spine fusion surgery.
In this study we will investigate whether changes in gutmicrobiota composition induced by allogenic donor fecal transplantation (from longterm type 1 diabetes mellitus patients with preserved beta cell function) compared to placebo, , has…
Rivastigmine will protect against the cognitive and memory side effects of ECT
A positive effect on mood is expected after LSD (20 µg) compared to placebo. The effect of LSD on mood is expected to differ depending on time of drug administration (morning vs evening).