421 resultaten
In the RIO study programme, the efficacy of rimonabant was examined. The next step is to assess the use of rimonabant, its safety and effectiveness in daily practice. In daily practice people also have other diseases, may use other medication and…
Several open-label pilot studies have shown a promising effect of intrapyloric botulinum toxin injection on symptoms in severe gastroparesis. However, data from randomized, double-blind, placebo-controlled studies are not yet available. We intend to…
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1: Long term use of fluoxetine causes the excitability of the primary motor area of the brain to change 2: Long term administration of fluoxetine causes the muscle activation patterns to change
DBS in the nucleus accumbens can lead to long-term improvement of obsessive-compulsive symptoms and funtioning, without unacceptable side-effects.
Prolonged antibiotic treatment of patients diagnosed with presumed PLD (as endorsed by the international ILADS guidelines) leads to better patient outcome than short-term treatment as endorsed by the Dutch CBO guidelines.
The TENLEP Trials proposal builds on the findings of the INFIR Cohort Study and the recommendations of the NLR-funded international Workshop on Neuropathology in Leprosy in the Netherlands in 2007. At this workshop, several key research questions…
Based on its general pro-hemostatic potential, prothrombin complex concentrate may be effective in (completely or partially) reversing the anticoagulant effect of the new antithrombotic agents Dabigatran and Rivaroxaban.
In the present study we will investigate the pharmacokinetic profile of three doses of sublingual testosterone, and measure subjective and physiological measures of sexual functioning in healty premenopausal women. The lowest effective dose of…
RhDNase can liquefy mucus in children with an atelectasis during mechanical ventilation, resulting in improved mucociliary clearance, less mucus retention and less airways obstruction, thereby enhancing the rate of resolution of an atelectasis.…
rhDNase improves lung function in children with persistent asthma who have persistent obstructive pulmonary function; Treatment of mucus impaction is an interesting alternative approach to treat peripheral airflow limitation in asthmatic patients.…
Based on systematic reviews concerning effective treatments in children with migraine a medical treatment (propanolol) as well as a non-medical treatment (relaxation therapy) appear to be effective compared to no treatment or placebo. however their…
Aetiology of late-onset depressive spectrum disorders may be different from the aetiology of early-onset depression. Concordant with the supposed aetiology of dementia, it has been postulated that chronic low grade immune activation plays a role in…
Imiquimod, an immunomodulator, has been shown safe and effective in the treatment of external genital warts caused by low risk human papillomavirus (HPV). Therefore, it is hypothesized that this topical treatment may also be effective against…
We hypothesize that systemic aPC will benefit patients with ALI/ARDS, as caused by inflammatory as well as infectious disorders, in terms of gas exchange, edema and capillary leak in these lungs, as well as in ventilator-days (duration of mechanical…
T-cell inhibition with Mycophenolate Mofetil (MMF) attenuates T-cell number, T-cell activation and T-cell – monocyte interaction, thereby minimizing the T-cell-driven inflammatory amplification loop. The latter will contribute to improvement of anti…
Type 2 diabetes patients frequently suffer from physical deconditioning and vascular disease. Although the exact mechanisms are unclear, microvascular changes and endothelial dysfunction appear to inhibit the oxygen transport and uptake in…
Adjuvant intra-articular corticosteroids reduce the clinical signs and symptoms of bacterial arthritis and improve outcome.
BB3 will improve kidney function in the immediate post-transplant period in patients who have received a DCD kidney transplantation.
Cholesterol lowering by low fat diet and lovastatin will also reduce very long chain fatty acids in patients with X-ALD.