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Assessment of Perinatal Outcome by uSe of Tocolysis in Early Labour: Nifedipine versus placebo in the treatment of preterm premature rupture of membranes.

The aim of the study is to assess whether in women with early PPROM tocolytics improve perinatal outcome.

Clinical trial of dabigatran on airway inflammation and coagulation in severe asthma.

We hypothesize that in patients with severe corticosteroid dependent asthma Dabigatran etexilate will: 1. Reduce airway inflammation; 2. Improve asthma control and pulmonary function; 3. Reduce hypercoagulability in the airways.