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Delegation of clozapine monitoring tasks to a Nurse Practitioner (condition A) is at least as safe as Treatment As Usual: physicians perform monitoring tasks themselves (condition B).
The hypothesis is that minimal invasive surgical ablation through video assisted thoracoscopic surgey as a primary treatment in patients suffering from (longstanding) persistent atrial fibrillation is superior to transvenous catheter ablation
An expectative management ('watchful waiting') is not inferior regarding the composite of mortality and/or necrotising enterocolitis and/or bronchopulmonary dysplasia in comparison with an early treatment regime in preterm infants with a…
Primary aim: 1. To investigate whether differences exist in the mitochondrial energy generating capacity of skeletal muscle of statin users with SAMS compared to statin users without SAMS and controls (non-statin users). Secondary aims: 2A. To…
In line with a previous pilot study we hypothesize that 3MDR will significantly decrease PTSD symptom severity in treatment resistant veterans with chronic PTSD in comparison with treatment as usual.
Children participating in daily sport classes will attain higher academic achievement than their counterparts who participated in the standard physical education classes incorporated in the school curriculum (1 hour/week).
In this RCT we investigate the effects of two school-based physical activity interventions (aerobic exercises versus coordinative exercises) in primary school children on executive functions and academic achievement. We hypothesize that both aerobic…
1. Gatekeeper training is effective in enhancing relevant skills 2. Gatekeeper training will diminish rates of (attempted) suicides at regional level 3. The intervention is cost-effective relative to routine medical care
Surgical procedures are accompanied by high levels of distress and pain in the adult as well as the pediatric population. Music interventions have shown to reduce this anxiety and pain in adult populations. In this study, we will investigate the…
At equi-analgesia respiratory depression from oxycodone is manifold greater compared to Tapentadol
In this randomized, single blinded controlled trial, we evaluate the role of ketamine as an analgesic component of procedural sedation. We compare the effects of propofol-ketamine versus propofol-alfentanil and propofol-remifentanil for achieving a…
The aim of the pilot trial is to: 1. evaluate the potential effectiveness and effect size of the online self-management program for patients with Cardiovascular Risk 2. to identify outcome measures most likely to capture potential patient benefit…
Multiproblem families (MPFs) provide a huge public health challenge because of socio-economic deprivation, psychosocial problems, parenting problems, domestic violence and rule-breaking behaviour. Therefore, there is a strong need for evidence-based…
Treatment of patients diagnosed with laryngeal cancer with total laryngectomy with or without (chemo)radiation often induces speech, swallowing and shoulder complaints. Speech, swallowing and shoulder exercises may prevent or diminish these…
Rates of neuropsychiatric symptoms are extremely high in institutionalized people with young-onset dementia. Neuropsychiatric symptoms are associated with reduced quality of life of residents and higher caregiver burden. Therefore, the Grip care…
Multidisciplinary, goal-attained and individualized rehabilitation after knee arthroplasty will result in more satisfaction regarding activities (level of activities and overall satisfaction) in younger knee arthroplasty patients (<65 years).
1) The TTCM is effective in terms of HR-QOL, pain, functional status, patient satisfaction and perceived recovery compared to regular care in trauma patients with at least one fracture. 2) The TTCM is cost-effective from a societal perspective (…
One-stop-shop concept, using real-time in vivo reflectance confocal microscopy as diagnostic tool is non-inferior to standard of care in the surgical management of new primary basal cell carcinoma
Diabetes Mellitus type 1 is an autoimmune disease that cannot be cured. Complications due to insufficient regulation of blood glucose by exogenous insulin reduce life expectancy and quality of life. Proinsuline-loaded Tolerogenic DCs are induce…