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Surgery versus stent for malignant gastro-duodenal obstruction.

To compare a surgical procedure (gastrojejunostomy, GJJ) with endoscopical stent placement in patients with malignant gastric outlet obstruction (GOO)

Transmural Nutritional Support.

To study the cost-effectiveness of transmural nutritional support (from admission to hospital until 3 months after discharge) in malnourished elderly patients, compared to usual care.

EValuation of Exercise and Angioplasty Trial.

A multicentre randomised controlled trial of low versus high threshold treatment in preterm infants with progressive posthaemorrhagic ventricular dilatation.

We hypothesize that in preterm infants with a gestational age below 34 weeks a low threshold intervention (progressive PHVD with a ventricular enlargement above the 97th centile for gestational age according to Levene and a diagonal width…

SMASHING in adults
Self-Management of Asthma Supported by Hospitals, Information and communication technology, Nurses and General practitioners.

A self-management programme guided by doctors and a specialist asthma nurse through information and communication technology will improve asthma related quality of life in a cost-effective way.

Dutch Intraventricular Trombolysis in Cerebral Haemorrhage study.

In patients with intraventricular haemorrhage caused by extension from an intracerebral haemorrhage, ventricular drainage combined with intraventricular thrombolysis improves three month outcome when compared to standard treatment.

The Delphi Trial - I(RCT)².

1. Is an early surgery treatment strategy in neurological intact patients, with rheumatoid arthritis and radiological signs of craniocervical pathology, (cost-) effective when compared to prolonged conservative treatment? What is the time-dependant…

SCION - Study on Cost-effectiveness of IPS regarding Open employment in the Netherlands.

1. Clients in IPS will get more competitive jobs, work more hours, and earn more wages than clients in standard services. 2. IPS will be more cost-effective than standard services in terms of combined medical and non-medical costs.

Does the addition of recLH (Luveris) to a regimen of recFSH (Gonal-F) and GnRH antagonist (Cetrotide) improve ovarian response and implantation rates in patients age >35 years undergoing IVF/ET?

The hypothesis of this study is that the addition of recLH (Luveris) to a protocol of recFSH (Gonal-F) and GnRH antagonist (Cetrotide) will improve the pregnancy rates in women over the age of 35 years undergoing IVF/ET.

Transmural occupational care for low back pain, A randomised controlled trial and cost-effectiviness evalution.

1. Is occupational transmural care for workers visiting outpatient clinics of a hospital more (cost-)effective on return-to-work than usual clinical medical care? 2. How is the program for transmural occupational care and its implementation (i.e.…

Hypitat.

Equivalence between maternal and neonatal outcome.

Prevention of Dementia by Intensive Vasculair Care.

To investigate if interventions aimed at vascular risk factors reduce the incidence of dementia or the burden of functional disability in elderly.

Participative ergonomics for mental health disorders, a randomised controlled trial and cost-effectiveness evalution.

Is participatory ergonomics for workers with common mental disorders more (cost-)effective on return-to-work than usual clinical medical care?

A randomized, controlled study into the effects of food on the behaviour of young children with attention-deficit hyperactivity disorder (ADHD).

The effects of foods on children with ADHD will be determined in a randomized, controlled trial. Can the results of earlier open-diet trials in the Netherland, i.e. 60% of the participants showed an improvement in behaviour of 50% or more, be…

The effect of early nutrition in high-risk infants on allergy prevention during the first 12 months of life.

Extension: The effect of nutrition given in the first 6 months of life in high-risk infants on allergy prevention up to 7 years of age.

It is expected that feeding a new hypoallergenic formula will result in a lower occurrence of AEDS (Atopic Eczema Dermatitis Syndrome) compared to giving a standard formula in infants with a high risk of developing atopic disease. Extension: To…

SLURP: Steroidinjections in LUmbosacral Radicular Syndrome.

Adding segmental steroid injections to usual care in the treatment of acute lumbosacral radicular syndrome will reduce pain and fasten recovery in general practice.

A randomized phase III study in previously untreated patients with biological high-risk CLL: Fludarabine + cyclophosphamide (FC) versus FC + low-dose alemtuzumab.

The hypothesis to be tested is that the outcome in arm B is better than in arm A.