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A Phase II multicenter study to assess the tolerability and efficacy of the addition of Bevacizumab to standard induction therapy in AML and high risk MDS above 60 years.

The hypothesis to be tested is that arm B is tolerable and that the outcome in arm B is better than in arm A.

Efectiveness of adding 'exposure in vivo' techniques to the return-to-work plan of workers with mental health problems: a cluster randomised controlled trial.

Occupational rehabilitation with a gradual return to work based on the principles of exposure in vivo will be more (cost)effective in reducing absenteeism than usual occupational rehabilitation.

Small scale living facilities for older people with dementia.

It is hypothesized that residents in small scale living facilities, compared to those in regular nursing home care, have a higher quality of life and functioning. In addition, it is hypothesized that their family caregivers experience less burden…

Laparoscopic ileocolic resection versus infliximab treatment of recurrent distal ileitis in Crohn's disease: a randomized multicenter trial (LIR!C-trial).

Laparoscopic ileocolic resection may be more effective than infliximab treatment in recurrent Crohn´s disease located in the terminal ileum improving quality of life and reducing costs.

Forlax versus Transipeg in constipated children.

Forlax and transipeg are equally effective in treating childhood constipation.

The effects of an exercise program on insulin sensitivity and plasma glucose levels in women at high risk for gestational diabetes.

Increasing levels of physical activity during pregnancy may be an effective strategy for the prevention of GDM.

Shared care for patients with chronic kidney disease in nephrology and general practice.

The hypothesis is that patients with chronic kidney disease will meet treating goals better when they are treated in a shared care model by a general practitioner, a practice nurse and with online consultation of a nephrologist.

Implementation of Colorectal Cancer Screening with FOBT in the Netherlands.

Implementation of Colorectal Cancer Screening with FOBT in the Netherlands is feasible

Gerandomiseerde trial naar kosteneffectiviteit van collaborative stepped care bij angststoornissen in de eerste lijn.

Collaborative stepped care for anxiety disorders in primary care is cost effective compared with Care As Usual.

Automatic Weaning Using
Adaptive Support Ventilation (ASV) –
Effect of an Early Weaning Protocol on Time till Extubation of Post–Coronary Artery Bypass Surgery Patients.

We hypothesize time till extubation of post–CABG patients can be shortened by using an early weaning protocol with ASV.

Has Manual Lymphatic Drainage (MLD), immediately applied after the axillary dissection during 5 months, a preventive effect on the development of arm lymphedema

1. Patients, receiving MLD and exercises after breast cancer surgery with axillary dissection are less at risk to develop an arm lymphedema, compared with patients receiving only exercises; 2. Patients, receiving MLD and exercises after breast…

Does mindfulness heighten emotional resilience against depression?
A study of gene-person-environment interactions.

1. Mindfulness training can be used to modify the ability to experience positive emotions from everyday life situations assessed with ESM (reward experience); 2. Experimentally induced increases in reward experience in daily life will reduce…

Nurse Practitioners at a clinical cardiological unit.

Patients will receive more continuous, more consistent and better (medical) care during their stay in the hospital when they are treated by nurse practitioners instead of medical interns or PhD students.

Fluvastatin and bisoprolol for the reduction of perioperative cardiac mortality and morbidity in high-risk patients undergoing non-cardiac surgery.

The general objective of the DECREASE-IV trial is to assess the clinical efficacy of beta-blocker therapy, statin therapy and combination therapy with beta-blockers and statins in patients undergoing major noncardiac surgery.

Individual health promotion on physical activity and nutrition among workers

It is hypothesized that long-term electronic communication through the web and e-mails (the Health Portal) provides efficient means to increase exposure to advice on healthy behavior and to facilitate adherence and sustainability.

The effect of music therapy interventions on assessment and behavior changes in the number of coping skills and social adequacy on newly admitted forensic psychiatric patients in the Netherlands.

The research tests two core propositions of music therapy research in forensic psychiatry: 1. There are some behavioral changes (on coping, social skills, and impuls regulation) of forensic psychiatric patients due to the music therapy treatment.…

Treatment of chronically depressed patients: a multisite randomised controlled trial testing the effectiveness of ‘Cognitive Behavioral Analysis System of Psychotherapy’ (CBASP) for chronic depressions versus usual secondary care.

CBASP is more effective and cost-effective than usual secondary care.

GECKO Outpatients Clinic

Does a multidisciplinary treatment program consisting of dietary advice, life style activity and psychological counseling, aimed at preschool overweight children , as well as their parents, influence the Body Mass Index?

Chloride secretion and childhood constipation.

Disturbed chloride secretion in constipated children versus controls.

A prospective Randomized Controlled Trial to Evaluate the Prevention of sudden cardiac death using implantable cardioverter defibrillators in dialysis patients.

In patients on dialysis therapy, aged 55-80 year, inplanatable cardiac device (ICD) therapy will reduce sudden cardiac (arrythmic) death.