325 resultaten
To test the safety and preliminary efficacy of a dual acute thrombolytic treatment consisting of a small intravenous (IV) bolus of alteplase followed by IV infusion of HisproUK against usual treatment with IV alteplase in patients presenting with…
We hypothesize that ingestion of potato protein increases muscle protein synthesis rates at rest as well as during recovery from exercise in young healthy males. We hypothesize that the muscle protein synthetic response to the ingestion of potato…
Aim of the MANCO study is to establish for once and for all that monitoring the effect of heparin during NCVI is essential to ensure the individual patient of safe and tailor-made anticoagulation. Not measuring the effect of the administered heparin…
It is hopthesized that a multidimensional implementation approach with multiple interventions integrated in the usual care will improve physical behaviour during hospitalization
Neutralizing antibody titers after fractional dosing of yellow fever vaccine are comparable to standard dose vaccination, ten years after primary vaccination
In the proposed study we will investigate the effect
Pre-hospital triage in patients with low risk of NSTE-ACS will reveal a large saving in health care resources in favor of the pre-hospital rule strategy with additional GP management. At 12 months the strategy will corroborate with a very low event…
Adolescence represents a crucial stage in the maturation of executive functioning (e.g. working memory and inhibition) and mental health (i.e. behavioral and emotional functioning, and self-concept), which both are important predictors of academic…
Hyperthermic intraperitoneal chemotherapy (HIPEC) has become standard of care for patients with peritoneal carcinomatosis of colorectal origin with a low/moderate abdominal disease load. In case of a peritoneal cancer index (PCI) above 20, a HIPEC-…
Electroconvulsive therapy (ECT) is the most effective treatment for severe depressions. Unfortunately, several cognitive side effects with a large pallet of different manifestations and impact often occur. For instance, postictal agitation ((PIA)…
We hypothesize that the subjective well-being of individual patients will show improvement after dose reduction compared with baseline, that is, patients will experience more positive affect, less negative affect and higher physical well-being…
Early identification of and specific interventions for older ED patients at highest risk of various poor outcomes contribute to the prevention of adverse events and lead to more efficient ED care.
To investigate whether myocardial blood volume (MBV) is reduced in patients with non-obstructive coronary artery disease and signs and symptoms of ischemia, relative to healthy controls. The specific aims are to investigate 1) if MBV is reduced in…
Traditionally, all surgically removed appendices and gallbladders are sent to the department of pathology for histopathological examination. This is most likely not necessary in appendices and gallbladders that are not suspicious for a malignancy…
To determine the presence or absence of central sensitisation in patients with Chronic Low Back Pain with radiation to the leg (CLBPr) and to determine the effect of segmental nerve interventions on central sensitisation.
We hypothesize to attain a drop of 20% of completed suicides in Noord-Brabant, the Netherlands.
The main objective of this study is to investigate which communicative strategies are most effective in increasing understanding and decreasing emotional impact in communicating increased risk for developing dementia status to persons with mild…
The primary hypothesis is that playing the serious game 'You & I' will be associated with an improvement of the mentalizing abilities in adults with mild to borderline intellectual disabilities. The secondary hypothesis is that…
Poor glycaemic control, indicated by an elevated HbA1c, is correlated to poor postoperative outcome in patients with diabetes mellitus undergoing surgery. However, improving glycaemic control before surgery has not been extensively studied so far.…