318 resultaten
To investigate whether 5 years of extended adjuvant treatment with letrozole results in an improved DFS compared to 2.5 years treatment in patients with early breast cancer previously treated with endocrine agents for 5 years.
The is no difference between an overdenture on 4 implants (test group) compared with an overdenture on 6 implants (control group).
Rationale: There is increasing evidence that Nicotine Replacement Therapy (NRT) may help adolescents to successfully quit smoking. However data on the effectiveness and safety of NRT among adolescents are limited and a large clinical trial of…
Inhibition of VEGF with Bevacizumab may have beneficial of deleterious effects on normal rectal microvasculature long time after radiation.
Subjects with pre-clinical arthritis will have a lower HRV compared to healthy subjects and but still a higher HRV compare to active RA-patients. Follow-up of individuals with pre-clinical arthritis will give insight in the change of HRV over time…
The overall objective of this study is to develop and evaluate the effectiveness of a tailored supportive intervention by a diabetes nurse to help people with type 2 diabetes cope with the occurrence of an acute cardiac syndrome (ACS) that might…
We hypothesize that the iron status in preterm infants born between 32 and 37 weeks (wk) GA might be insufficient.
The effectiveness of a manualized cognitive-behavioral treatment (CBT) for clinically anxious children will be tested in a sample of Dutch children (aged 8-12 years) who are assigned to one of three Dutch community agencies in Arnhem and Nijmegen.…
The (long term) effectiveness of a school-based universal depression prevention program (“Op Volle Kracht”) will be tested in a Dutch sample of adolescents (aged 12-14 years). It is expected that adolescents who receive the intervention will show…
Effects of acupuncture (add on) treatment are investigated.
To evaluate whether nitrofurantoin treatment for women with asymptomatic bacteriuria is effective in reducing the risk of preterm delivery and/or pyelonephritis (primary outcome) and bad neonatal outcome (secondary outcome). In addition, assessing…
Prucalopride accelerates gastric emptying and increases esophageal contraction amplitude and LES pressure and subsequently reduces gastroesophageal reflux.
A high dose of rosuvastatin significantly decreases or halt the progress of the necrotic core volume present in a non-intervened coronary segment as assessed by IVUS-VH.
We hypothesize that a combined intracoronary pressure-flow measurement directly after percutaneous coronary intervention is a measure for predicting the occurrence of microvascular obstruction in the days following the acute event.
Previously, Knower et al. suggested that baseline oxygen saturation (SpO2) of 95% or less is a good screening test for oxygen desaturation during a 6MWT (sensitivity: 73%; negative predictive value: 84%), especially in COPD patients with a DLCO…
A protein supplement has a positive effect on muscle mass, muscle strength and physical functioning during a weight loss trial in overweight elderly.
Treatment starting with a low dose dipyridamole reduces the side-effect headache with 25%.
Before we start with our research on assessing the diagnostic value of TMS-EEG in epilepsy, we perform this pilot study to investigate a number of methodological aspects. To be able to develop a sound protocol these aspects need to be explored in…
We hypothesize that the WavSTAT optical biopsy system may improve the endoscopists ability to detect and distinguish suspicious lesions in the Barrett oesophagus, while reducing the need for extensive biopsy protocols during surveillance endoscopies…
The aim of this study is to develop and evaluate a training program for CHWs in early detection or recognition of HIV suspected oro-facial lesions and to build their capacity and skill in mobilizing the community on HIV suspected oro-facial lesions…