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A Team-level Participatory Approach Aimed at Improving Sustainable Employability of Long-term Elderly Care Workers

The main objectives of this study are: • To gain insight into the effectiveness of the Healthy Working Approach on need for recovery in elderly care workers over one year. • To gain insight into the process of implementing the Healthy Working…

Observational cohort of patients treated with stereotactic radiotherapy for Oligo LYMPh nOde and other soft tissue metastasiS; the OLYMPOS cohort

The main clinical challenge remains to identify patients who may benefit from aggressive local treatment (stereotactic radiotherapy, SBRT) of soft tissue oligometastases: for which patients can systemic treatment be postponed? Patients who are…

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To evaluate the incidence, risk factors and perinatal morbidity and mortality due to CA after TTTS treated with fetoscopic laser surgery

WriteWell: Effects and mechanisms of different ways of writing about distressing events

(1) Written imaginal exposure results in beneficial effects compared to no-intervention (2) Beneficial effects are greater for written imaginal exposure in the past tense than for written imaginal exposure in the present tense

Onderzoek naar de effecten van het medicijn liraglutide bij patiënten met een type suikerziekte (diabetes) die veroorzaakt is door het gebruik van antipsychotische medicijnen.

Liraglutide is an effective and safe treatment modality in metformin-treated patients suffering from schizophrenia with anti-psychotic drugs-related diabetes mellitus.

Online guided vs. unguided cognitive behavioral therapy for distress in people who lost a loved one during the COVID-19 pandemic: A controlled trial

Our first hypothesis is that both guided and unguided online CBT lead to a decrease in the severity of PCBD, PTSD, and depression symptoms. Our second hypothesis is that people allocated to the guided online CBT group will show a stronger decrease…

The evaluation of pelvic floor muscle tone depending on how the probe was placed.

1. A higher resting and funtional PFM activity is observed in more distal areas from the introitus of the vagina. 2. A higher resting and funtional PFM activity is observed on the anterior wall of the vagina

Use of intraoperative cerebral and renal region Near infrared spectroscopy to predict postoperative outcome; a prospective observational study

We hypothesize that lower renal region or cerebral NIRS values are correlated with a higher incidence of postoperative AKI in this study population

Gerandomiseerde studie naar het monitoren van longfunctie bij de opvang van te vroeg geborenen bij de geboorte

To test the hypothesis that observing the data and waveforms displayed on an respiratory function monitor during the provision of positive pressure ventilation to preterm infants at birth will increase the proportion of tidal volumes within a…

DXA scan comparison

We hypothesise that there will be no (substantial) differences between both scans for all relevant parameters (e.g. fat mass, lean mass, and bone mineral density) when the same subjects are measured on the same day, under the same conditions.

Comparison of Point-Of-Care testing and venouS blood glucose at the oral Glucose TolerAnce test in pRegnancy

The aim of this study is to determine a high level of agreement between readings obtained from the plasma levels and the Roche Accu-Chek Inform II.

VIM-positive Pseudomonas aeruginosa - the pre-SAMPAN study.

VIM-positive Pseudomonas aeruginosa can be found in other body sites besides throat and rectum, which are currently used as the standard surveillance culture sites.

COACH-pilot study; COgnition After intraCerebral Hemorrhage

Cerebral amyloid angiopathy is an important predictor for cognitive decline after intracerebral hemorrhage

Safety and pharmacokinetics of antipsychotics in children 2: Studying TDM in an RCT

We hypothesize that therapeutic drug monitoring of risperidone in children with an autism spectrum disorder and comorbid behavioral problems will reduce metabolic side effect burden, while retaining clinical effectiveness.

Sirolimus-coated balloon versus drug-eluting stent in native coronary vessels

The hypothesis of the TRANSFORM II study is the non-inferiority of Sirolimus Coated Balloon versus Everolimus Eluting Stent in terms of Target Lesion Failure

Beter Samen Beslissen

We hypothesize that clinicians exposed to this intervention are more likely to adopt SDM behaviors than clinicians who do not. A secondary aim is to evaluate whether patients perceive more involvement in the decision-making process.

IEMO 80-plus thyroid trial.

1. Does Levothyroxine treatment for subclinical hypothyroidism give multi-modal benefits for the oldest old people with subclinical hypothyroidism? 2. Are benefits seen across a wide range of outcomes, including prevention of cardiovascular disease…

The effect of Art Therapy in individuals with Personality Disorders cluster B/C: a RCT.

Het effect van beeldende therapie bij personen met persoonlijkheidsstoornissen cluster B/C: een RCT.

In this randomised controlled study, the effects of art therapy is examined on psychological functioning of patients with a personality disorder. It is expected that art therapy results in less personality pathology, more acceptance, and less…

Predicting and Understanding Depression Prevention Techniques: a mechanistic cross-over trial of mindfulness vs. fantasizing to reduce vulnerability for depression

I. Test whether psychological and psychophysiological indices of PC are differentially affected by fantasizing vs. mindfulness in remitted MDD patients and HC: Pre-and peri-intervention changes will be examined using within-subject and between-group…

Echo flow versus (non-)invasive haemodynamics 2

We aim to compare the accuracy of ultrasound derived blood flow parameters from the carotid artery to pulse-contour derived cardiac output and non-invasive cardiac output measurements. Our motivation is to develop a non-invasive, radiation-free,…