322 resultaten
We hypothesize that age-associated changes of immune function contribute to impaired anti-melanoma immunity and that these changes underlie the higher incidence and the more aggressive behaviour of melanoma in the elderly. We think that the baseline…
The aim of this study is threefold: (1) to test the effectiveness of OVK in reducing symptoms of depression compared to treatment as usual (TAU), (2) to identify mechanisms that can explain program effects, and (3) to test the effects of OVK on…
While head and neck surgeons aim for a 1 cm healthy tissue margin during resection of OSCC, pathological examination often reveals a smaller margin. Our hypothesis is that this occurs due to shrinkage of mucosa following the resection and due to the…
Currently, health care and medical decision-making for older people are often insufficiently patient-centred. Communication about people’s needs and preferences is typically postponed until acute events necessitate short-term medical decision-making…
Prevention of pressure ulcers is a major challenge since there is still an unacceptably high number of clients in nursing homes, care homes and residential care centers where pressure ulcers arise after intake of new residents. The study involves a…
To study the effect of Neocate elemental nutrition on the esophageal eosinophilic inflammation in adult patients with eosinophilic esophagitis. Secondary: to study the effect of Neocate elemental nutrition on esophageal and intestinal mucosal…
The hypothesis is that rapid on-site evaluation increases diagnostic accuracy of EUS-FNA aof lymph nodes
Current practice variance in adult patients with chronic rhinosinusitis with nasal polyps (CRSwNP) is not efficient. Endoscopic sinus surgery (ESS) is the most common ENT operation in adults in the Netherlands. The objective of the present study is…
We expect that the intervention will improve physical functioning, will be more cost-effective, and will reduce somatisation, depression and anxiety symptoms.
The drugsurvival in the combination group will be better than the survival in the monotherapy group.
A strategy restricting nebulisation of mucolytics and bronchodilators to patients with sputum plugging is as effective as, but cheaper and safer than, a strategy using routine nebulisation in all intubated and mechanically ventilated ICU patients.
When caffeine has a direct effect at birth and improves respiratory effort, then this treatment could have the potential to decrease the chance that preterm infants show respiratory failure during transition. The benefit of this is that ventilation…
The primary hypothesis is that treatment with baclofen will decrease the risk of relapse in GHB use and increase the duration of abstinence after detoxification in recently detoxified GHB dependent patients Secondary hypotheses include: 1.treatment…
The MBCP programme as well as the FCC programme will reduce i.e. fear of childbirth, stress, labor pain and increase adaptation to perinatal period.
To assess perioperative physical activity and fitness, and muscle strength in cardiac surgical patients and to explore the association with POCD after heart surgery
We expect that the disproportionally strong clinical effects of fingolimod in relapsing remitting multiple sclerosis can be explained by enhanced functional adaptation mechanisms of the brain and that enhanced functional adaptation will be sustained…
Disturbances in the circadian rhythm could be a possible cause for development of delirium.
Peroperative fluorescent imaging of the bile ducts will improve visibility and results in early identification of the common bile duct and the cystic duct during laparoscopic cholecystectomy in patients at risk for bile duct injury.