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We hypothesize that active monitoring of infants with stable centered DDH (Graf type IIb/IIc) does not result in a lower proportion of infants with normal hips (success: acetabular index lower than 25 degrees on radiograph) at the age of 12 months…
We hypothesize that the ceftriaxone monotherapy strategy is non-inferior for mortality and for nephrotoxicity a strategy of ceftriaxone monotherapy is superior to a strategy of cefuroxime combined with short course aminoglycosides.
We expect that the test characteristics of saline infusion sonography will be higher than the test characteristics of the transvaginal ultrasound. We expect that the saline infusion sonography is less painful and has a lower complication rate than…
The main objectives of this study are: • To gain insight into the effectiveness of the Healthy Working Approach on need for recovery in elderly care workers over one year. • To gain insight into the process of implementing the Healthy Working…
The main clinical challenge remains to identify patients who may benefit from aggressive local treatment (stereotactic radiotherapy, SBRT) of soft tissue oligometastases: for which patients can systemic treatment be postponed? Patients who are…
The lifestyle program will improve the quality of life and lifestyle behavior, and will decrease the healthcare utlization, comorbidity and cancer recurrence rates.
Gastric fluid volumes in patients with a 6-4-0 pre-operative fasting regime are comparable to patients with a 6-4-2 pre-operative fasting regime
We hypothesize that therapeutic drug monitoring of risperidone in children with an autism spectrum disorder and comorbid behavioral problems will reduce metabolic side effect burden, while retaining clinical effectiveness.
With use of this platform by GPs in Zwolle-region, the number of unnecessary referrals to Isala Movement Centre will decrease.
Sex differences in renal physiology is a vastly understudied area, despite known differences in sex-specific rates of chronic kidney disease. Renal function decline is accelerated in men compared to women, suggesting a potential harmful role for…
From survey studies it is suggested that patient preference and satisfaction will be in favour of oral JAK inhibitors over parenteral biologics. 5,6,7 We want to establish the treatment preference of patients with active RA and compare the treatment…
The analysis of protease activity from saliva and the salivary biofilm, using these substrates, may provide a new layer of information useful in the discovery of prognostic markers with respect and related to the histopathological features of oral…
We hypothesize that the UC Diet (UCD) can improve induction of remission rates when administered with a 5ASA regimen to pediatric patients with mild-moderate UC vs. 5ASA regimen alone.
The eNose will be able to discriminate stable patients from patients with CLAD and ACR, and between ACR and CLAD
Primary question is whether the intended cost effectiveness / cost utility study is feasible. The study is feasible if at least 50% of the participants fulfilling the inclusion criteria are randomized in this pilot study.
Respiratory motion will be maximally reduced during compensated prolonged breath-holding where gradual lung deflation is abolished by mechanical re-inflation of oxygen, and high frequency ventilation is expected to be equally effective. Regularized…
Study Hypotheses: We hypothesize that there will be: 1) High ratings of treatment acceptability (treatment satisfaction ratings) from participants 2) A reduction in depression (PHQ-9) and anxiety (GAD-7) symptoms, and perceived stress (PSS) scores…
Compare the gametocytocidal and transmission reducing activity of artemether-lumefantrine (AL) with and without a single dose of 0.25mg/kg primaquine (PQ) and sulfadoxine-pyrimethamine with amodiaquine (SPAQ) with and without single dose of 1.66mg/…
The expectations are that the FVC application will provide a higher completion rate and more correct and legible data than the conventional paper FVC.
The monitoring performance of a wireless alternative for cardiorespiratory monitoring in neonates is equivalent (non-inferior) compared to routine monitoring with adhesive electrodes.