5605 resultaten
Administration of fluoxetine during late brain development (adolescence), but not in adulthood, will result in abnormal outgrowth of the 5-HT system. This long-lasting disturbance of the 5-HT system may be visualized using MRI techniques and can…
The aim of this study is to investigate an abridged version of an online health training, based on cognitive behavioral therapy components, that is focused on the optimization of health. It is expected that this online health training will have a…
The stepped care approach will lead to a significantly reduced incidence of clinical anxiety and depression in two years and will reduce symptoms level compared to usual care.
Sex differences in renal physiology is a vastly understudied area, despite known differences in sex-specific rates of chronic kidney disease. Renal function decline is accelerated in men compared to women, suggesting a potential harmful role for…
We hypothesize that muscle protein breakdown (i.e. amino acid release) is related to increased glutamine utilization by immune cells, gluconeogenesis and synthesis of acute phase proteins.
This study aims to apply state-of-the-art immune tests quantifying the immunosuppressive state in individuals, and the relationship between these pharmacodynamic tests and the pharmacokinetic profile (in whole blood and intracellular) after a single…
Training for the HandbikeBattle and handbike training in general, will have a positive effect on physical health, physical fitness and quality of life in wheelchair dependent individuals.
From survey studies it is suggested that patient preference and satisfaction will be in favour of oral JAK inhibitors over parenteral biologics. 5,6,7 We want to establish the treatment preference of patients with active RA and compare the treatment…
Systematic screening for type 2 diabetes in high-risk obese subjects, identified from the general population, can significantly reduce the diabetes-related cardiovascular morbidity and mortality by at least 25% compared with not offering a screening…
1. A screening instrument, consisting of predictive factors, can be used to predict which employees are at risk for sickness absence due to psychosocial health complaints; 2. Coaching is effective in preventing sickness absence and improving general…
Therapeutic ultrasound will be more effective than placebo ultrasound at reducing pain and improving function in chronic low back pain patients.
Adolescence represents a crucial stage in the maturation of executive functioning (e.g. working memory and inhibition) and mental health (i.e. behavioral and emotional functioning, and self-concept), which both are important predictors of academic…
Hyperthermic intraperitoneal chemotherapy (HIPEC) has become standard of care for patients with peritoneal carcinomatosis of colorectal origin with a low/moderate abdominal disease load. In case of a peritoneal cancer index (PCI) above 20, a HIPEC-…
Adolescents with emotion regulation problems who followed the Emotion Regulation Training will show improvement on the following items: 1. Symptoms of emotional dysregulation; 2. Positive and negative coping behaviour; 3. Stress symptoms in the…
1. Mindfulness training can be used to modify the ability to experience positive emotions from everyday life situations assessed with ESM (reward experience); 2. Experimentally induced increases in reward experience in daily life will reduce…
Mindfulness improves wound healing
To study if a Mediterranean diet (MD) followed by lean donor fecal microbiota transplantation (FMT) has synergistic superior beneficial effects on peripheral insulin sensitivity and (small) intestinal microbiota composition as compared to…
Remifentanil PCA 20 micrograms is an effective dose for pain relief in labour.
Hemodynamic optimization during and after colorectal surgery results in improved intestinal perfusion, sustained intestinal barrier and improved postoperative recovery.