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Oral PHA-022121 for the acute treatment and prophylaxis Of angioedema attacks in Patients with Acquired C1-Inhibitor Deficiency

We hypothesize that PHA-022121 will be more effective in both the treatment and prophylaxis of acute angioedema attacks in patients with acquired C1-inhibitor deficiency when compared to placebo.

Inclusive invasive physiological assessment in angina syndromes - Angina with no obstructive coronary artery disease

In patients with ANOCA, identification of specific endotypes of vascular dysfunction with intracoronary testing, followed by pharmacological and nonpharmacological interventions aligned to the identified endotype, leads to better control of angina…

FLOW

We expect that the access-related intervention rate and medical costs will be reduced by 40% when correction of vascular access stenosis is triggered by clinically apparent access dysfunction rather than by asymptomatic flow reduction detected by…

ProtEE study

The course of resting energy expenditure (REE), measured by indirect calorimetry changes based on standard versus high enteral protein feeding in the ICU.

Nicotine salts

We expect to find that e-liquids with nicotine salts taste milder and are easier to inhale than e-liquids with free-base nicotine. More specifically, we hypothesize that e-liquids with nicotine salts, in comparison to free-base e-liquids: 1. are…

Taste function after chorda tympani injury

Sacrificing the chorda tympani causes less taste disfunction than stretching or damaging the chorda tympani nerve.

A randomized, double-blind crossover trial to investigate the effects of oliceridine and morphine on ventilatory drive and pain relief in healthy older subjects - a population pharmacokinetic/pharmacodynamic modeling study

It is expected that oliceridine has a better profile concerning dose-related analgesia and dose-related side effects, compared to morphine.

A Randomized, Double-blind, Placebo-controlled Trial on the Prevention of Chronic Postoperative Pain after Inguinal Hernia and Knee Surgery by Postoperative Treatment with Tapentadol

We hypothesize that treatment with Tapentadol will reduce the development of chronic postoperative pain by enhancing or maintaining CPM responses and possibly reducing central sensitization. We hypothesize that a 4-week treatment with Tapentadol…

Lactoferrin in the treatment of Long COVID

To reduce fatigue symptoms with the use of a bovine lactoferrin supplement in patients suffering from Long COVID.

Low Dose Naltrexone for the induction of remission in patients with mild to moderate Crohn’s Disease
that failed conventional treatment

The aim of this study is to prospectively assess the efficacy of LDN as induction therapy in CD.

Ambroxol in Gaucher disease 3: n-of-1 series

Based on previous studies, we will expect that ambroxol improves neurological manifestations in patients with GD3.

Dutch multidomain lifestyle intervention in older adults at risk of cognitive decline

The primary objective is to investigate the effectiveness of a personalized 2-year multidomain lifestyle intervention on cognitive performance in older adults at risk of cognitive decline.