100 resultaten
Otosclerosis is an isolated ear disorder which can cause hearing and balance impairment. The cause of these symptoms is a disturbed bone metabolism confined to the area of the otic pit, the embryologic predecessor of the inner ear. Most patients…
To investigate whether the clinical outcome is similar after the implantation of the Resolute Integrity stent versus the Promus Element stent (non-inferiority test).
There is clear medical need in pediatric high-grade MDS and JMML to control disease pre-SCT without the disadvantages associated with intensive chemotherapy. So far no agents have been successfully applied in this window, or are specifically…
1. The point of the skin with best possible transcutaneous nerve stimulation correlates with the point of the skin most superficial to the nerves stimulated within a range of 3 mm; 2. Ultrasound will reveal a significant number of sensitive…
The objective of the study is to identify factors associated with anterior knee pain after primary total knee replacement.
We hypothesize that a treatment algorithm that is based on a simple validated measure of health status (CCQ) improves quality of life (as measured on a separate scale) and other classical COPD outcome measurement parameters such as exacerbation…
The primary research hypotheses are: 1. Patients who follow the Onco-Move program will achieve better physical fitness levels, as assessed by objective performance tests, and will report less fatigue than patients in the usual care control group; 2…
Public health authorities have recognized lack of hand hygiene (HH) as one of the important causes of preventable mortality and morbidity at population level. Both at national (UK, USA, Dutch VMS) and international levels (WHO) poor HH has been…
What is the prevalence of dysplasia or carcinoma in patients with Crohn's disease that undergo surveillance endoscopy with chromoendoscopy-guided confocal laser endomicroscopy?
1. Cooling to 34, 34.5 or 35°C by means of a surface cooling device, started within 4.5 hours after the onset of acute ischaemic stroke and maintained for 24 hours in awake patients on a stroke unit is safe; 2. In awake patients with ischaemic…
The hypothesis is that offering CBT in a group format while discontinuing antidepressant medication will reduce the high relapse rates in remitted anxiety disorder patients who discontinue pharmacological treatment.
In the present study we will investigate the pharmacokinetic profile of three doses of sublingual testosterone, and measure subjective and physiological measures of sexual functioning in healty premenopausal women. The lowest effective dose of…
After receiving PST, stroke patients will have a more effective coping style followed by a better quality of life.
A four day adminstration of N-acetylcysteine (3600 mg/day) will reduce craving, withdrawal symptoms and the bias towards nicotine related cues compared to a four day administration of placebo in nicotine dependent subjects.
ICG alone without being absorbed to albumin can be used for near-infrared fluorescence SLNB in breast cancer patients.
The mission of the chronic ITP registry is to improve the knowledge of the treatment and course of patients with persistent of chronic ITP. The objective of the registry is to get more insight in the number of patients that need a treatment for…
1. Is a multidisciplinary cognitive behavioural lifestyle program more effective in losing weight and permanent weight loss for women with PCOS and obesity then regular care? 2. Is a multidisciplinary cognitive behavioural lifestyle program in…
Adding a Combined Psychological Intervention to a very low calorie diet is more effective then a very low calorie diet followed by usual care in maintaining weight loss and improving glycaemic control, cardiovascular risk score, psychological…
We hypothesize that genetically programmed developmental differences in adipocytes are under direct regulation of fecal flora composition which thus plays an important role in obesity, body fat distribution ans systhemic inflammation.
The individual patient can make a well-informed choice for a treatment by using audio-visual aids.