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Otosclerosis is an isolated ear disorder which can cause hearing and balance impairment. The cause of these symptoms is a disturbed bone metabolism confined to the area of the otic pit, the embryologic predecessor of the inner ear. Most patients…
The Rotterdam Daily Exercise Project leads to less overweight, improved fitness, healthier food habits and healthier exercise habits.
To evaluate the cost-effectiveness of therapies for male subfertility.
Health outcomes for people at risk of or suffering from non-communicable lung diseases in low-resource settings will be improved by developing capacity for implementation of evidence-based interventions for prevention, diagnosis and treatment in…
We expect that planned visits at the outpatient clinic are unnecessary due to low percentage of treatment changes. Furthermore, we expect that treatment changes will appear at unplanned visits.
We purposefully selected four interventions, three groups with different roles and six countries because we expect acceptability to differ within these dimensions. There are specific hypotheses (H) for part of the possible contrasts. We will explore…
This study will use a Randomized Controlled Trial (RCT) to evaluate the effectiveness and underlying mechanisms of the video game Mindlight, a newly developed anxiety-reducing training for children. Mindlight and a control game will be played for…
In this project the hypothesis is tested that the community pharmacist-led CATI care programme in patients using cardiovascular medication, will have a beneficial effect on patients’ adherence to cardiovascular medication and improves clinical…
Muscular counterpulsation (MCP) is a new treatment option which seems to improve hemodynamics but might also have positive effects on muscular and vascular function. Additionally, it is non-invasive and does not seem to have relevant side effects.…
Life review therapy will have a positive effect on the level of depressive symptoms of nursing home inhabitants.
A novel approach/algorithm for individualised risk assessment of COPD exacerbations, which integrates both microbiological data and clinical information, improves the accuracy of exacerbation prediction in COPD patients over methods based on…
Despite appropriate antimicrobial therapy and supportive care, septic shock is still a major cause of mortality and morbidity. Within the last decade, a broad body of evidence suggests a potential role for mesenchymal stromal cell (MSC, a…
Feasibility and reliability of prehospital triage in patients with thoracic complaints/pain appropriate to a suspicious ACS
To identify high risk patient groups for development of knee osteoarthritis (OA) in a cohort 9-10 years after meniscus, cruciate ligament and cartilage lesions.
Usage of the 'Moveosiphon' sonothermal sink disinfection device prevents leads to a persistant decrease in colonization with multiresistant Pseudomonas aeruginosa
The primary objective of the study is to study the safety of MMR booster vaccination in JIA patients by measuring JIA disease activity and the occurrence of measles, mumps or rubella infection. The next primary objective is to evaluate the efficacy…
Hypothesis 1: Refractory epilepsy patients will report a significant increase in quality of life, one and two years after ANT DBS or VNS treatment. Hypothesis 2: Refractory epilepsy patients will report a significant seizure frequency reduction…
To investigate the newly developed method to study lung density changes using CT-scan, in a small patient population. The relationship between radiation induced lung density changes and dose distribution/tumor location will be investigated.