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Effects of transfusion of leukocyte-depleted erythrocytes in cardiac valve surgery on postoperative complications.

To investigate the role and mechanisms of leukocytes in allogeneic erythrocyte concentrates on postoperative complications, as MODS, infections and death.

The effect of birch pollen immunotherapy on hazelnut allergy.

The severity of hazelnut allergy will decrease as an additional effect by birch pollen immunotherapy.

Low dose vitamin K to improve therapeutic quality control of oral anticoagulant treatment: a randomized double-blind placebo controlled trial.

1. Oral anticoagulant control is less stable at a low average intake of vitamin K; 2. As a consequence, a low dose vitamin K supplement results in a more stable anticoagulant effect in patients using vitamin K antagonists (VKA); 3. Dietary intake…

Validation study to explore potential outcome parameters for a study with anti-IL-13 in allergic syndrome/asthma.

Primary study objectives: 1. To test the reproducibility, in atopic subjects with a clinically stable allergic rhinitis, of: a. SPT; b. Relevant markers of allergic rhinitis and atopy in peripheral blood; 2. To validate the following assays for…

Primairy prevention of atopic disease by perinatal administration of probiotics.

Administration of probiotics to pregnant women from an atopic family and subsequently to their high-risk newborns results in prevention of the incidence of or in a decrease of the severity of atopic disease during infancy.

Een gerandomizeerde, dubbelblinde en placebo-gecontroleerde exploratieve studie ter evaluatie van een één week durende orale behandeling met R129160 (60 mg/dag) bij patiënten met chronische idiopathische urticaria.

Onderzoek naar de werkzaamheid, veiligheid en tolerantie van oraal R129160, 60 mg/dag in volwassen patiënten met chronische idiopathische urticaria (CIU).