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We hypothesize that the epigenetic changes that are related to childhood trauma provide a treatment target for succesful treatment with SAMe of persistent depression in bipolar disorder
Infant formulae with higher levels of milk fat result in improved fatty acids absorption as compared to standard formula.
We hypothesize that in healthy individuals with Early-life stress (ELS), THC, which directly targets the endocannabinoid system, is more effective than hydrocortisone in improving stress adaptation and extinction learning in an experimental model of…
If COMET increases the saliency of positive autobiographical memories, then memories that are activated during COMET (relative to no intervention control) should show an increase over time on all primary outcome measures, irrespective of medication…
The study will assess drug-induced change in performance in divergent thinking and goal-directed behaviour when comparing psilocybin to placebo, before and after an induction of stress. Additional study parameters include frontal-subcortical…
The preventive HA formula will show on average a 40% risk-reduction for AD (54% when AD is not present in family history and 22% when AD is present in the family history) as compared to a standard formula. 2) The preventive HA will show a 30% risk…
Eosinophils play an important role in the inflammatory processes in the lung of asthmatic patients. Mepolizumab inhibits homing of these cells. The hypothesis is tested that mepolizumab affects the kinetics of these cells in blood and sputum.
1. The use of food supplements containing vitamin C with quercetin and other flavonoids can reduce inflammation clinically (assessed by means of periodontal parameters), and systemically (assessed by means of biomarkers), in patients diagnosed with…
By making a child-profile (360°CHILDoc) online available for parents and youth, they will be more satisfied about the health service Accessibility of the Preventive Child and Youth Health Care (CYHC) and the integral CYHC- information about child…
The study products will result in different stool consistency compared to reference product
We hypothesize that PESF improves aerobic and anaerobic performance in talented speedskaters.
With help of the TOF watch, a reduction in muscle relaxation can be observed earlier. In this way, peroperative events (pain or contractions by the patient) can be prevented. Less peroperative events lead to less postoperative pain.
1. Leadless Pacemaker (LP) therapy is superior to current standard-of-care (SOC) with regard to procedure-related complications in Transcatheter Aortic Valve Replacement (TAVI) patients who develop conduction abnomalies (CA). 2. LP therapy reduces…
Tranexamic acid reduces the necessity for surgery and increases quality of life.
We hypothesized that exposure to WDYD+ (experimental arm) is more effective in changing alcohol drinking (primary outcomes) and its determinants (secondary outcomes) at 2 weeks and 6-month follow-up (i.e., after the intervention period), compared to…
The expectation of this study is that shorter duration of plaster cast immobilization is beneficial for the patients.
We hypothesize that injecting an inert/biodegradable spacer between the dermis and the most superficial layer of the planned target volume (PTV) could remove the skin from the high dose volume, and this would result in a significant reduction of…
Regularly scheduled administration of paracetamol, compared to placebo, leads to better quality of life, daily functioning, mood, and less pain, care dependency, behavioural problems and psychotrophic medication use.