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We hypothesize that sympathetic activation of human BAT is mainly mediated by the ADRB2 rather than the ADRB3
Rationale: Loss of smell (anosmia) is common in COVID-19 infections. Most patients regain normal smell within 4 weeks, but in 6-8% the smell does not fully recovery. These persistent smell disorders greatly influence daily life. It is thought that…
Based on previous studies, we will expect that ambroxol improves neurological manifestations in patients with GD3.
We hypothesize that PHA-022121 will be more effective in both the treatment and prophylaxis of acute angioedema attacks in patients with acquired C1-inhibitor deficiency when compared to placebo.
We expect that the access-related intervention rate and medical costs will be reduced by 40% when correction of vascular access stenosis is triggered by clinically apparent access dysfunction rather than by asymptomatic flow reduction detected by…
The primary objective is to investigate the effectiveness of a personalized 2-year multidomain lifestyle intervention on cognitive performance in older adults at risk of cognitive decline.
We expect to find that e-liquids with nicotine salts taste milder and are easier to inhale than e-liquids with free-base nicotine. More specifically, we hypothesize that e-liquids with nicotine salts, in comparison to free-base e-liquids: 1. are…
Sacrificing the chorda tympani causes less taste disfunction than stretching or damaging the chorda tympani nerve.
It is expected that oliceridine has a better profile concerning dose-related analgesia and dose-related side effects, compared to morphine.
The aim of this study is to prospectively assess the efficacy of LDN as induction therapy in CD.
The course of resting energy expenditure (REE), measured by indirect calorimetry changes based on standard versus high enteral protein feeding in the ICU.
In patients with ANOCA, identification of specific endotypes of vascular dysfunction with intracoronary testing, followed by pharmacological and nonpharmacological interventions aligned to the identified endotype, leads to better control of angina…
We hypothesize that treatment with Tapentadol will reduce the development of chronic postoperative pain by enhancing or maintaining CPM responses and possibly reducing central sensitization. We hypothesize that a 4-week treatment with Tapentadol…
The test product supports normal physical growth in healthy term infants
We hypothesize that restoration of gut microbiota diversity (by using donor FMT enriched in Desulfovibrio strains) could have explicit beneficial effects on glucose metabolism and NAFLD (via improved fructose catabolism), which is driven by…
We hypothesize that methylphenidate improves ADHD manifestations in adults with (late-diagnosed) PKU.
1. We hypothesize that the ingestion of 30 g of collagen peptides and 30 g of free amino acids (matching the profile of collagen peptides) will result in greater myofibrillar and connective tissue protein synthesis rates in skeletal muscle tissue at…
The hypothesis of this study is that SVF alleviates pain and increases maximal interincisal mouth opening in patients with TMJ osteoarthritis.
Perioperative magnesium infusion (maintaining a serum concentration between 1.5-2.0 mmol/L) is able to clinically significantly reduce the incidence of perioperative atrial fibrillation (POAF).
Supplementation with an over the counter multivitamin and mineral supplement (New Care Multi®) for 24 weeks in the winter and spring can prevent infections in patients with inflammatory bowel disease in remission with immunomodulators or biological…