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Objective: 1. To determine protein balance in septic, critically ill children at baseline and during a Hyperinsulinemic Euglycemic Clamp, while receiving standard or high protein intake based on age group; 2. To assess insulin sensitivity and…
Low frequency rTMS has inhibitory effects on underlying cortical tissue, which suggests a therapeutic value against the pathological overactivation of speech cortex in schizophrenia patients with voice hallucinations. NeuroImaging studies point to…
Technology in determination of disease-specific protein profiles of bacteria in vitreous of patients with endophthalmitis after cataract surgery. Protein profiles of vitreous samples from endophthalmitis patients with a negative culture will be…
We expect that both treatment conditions are better than sham and that fMRI guided rTMS is superior to rTMS directed to the left TP.
Zevalin consolidation after first line therapy with R-CVP in patients with follicular lymphoma grade 1-3a, stage 2-4 induces conversion of PET positive PR to CR in more than 40% of patients.
We hypothesise that (restoration of) a adequate circulation in early septic shock is reached sooner and with less vasoactive support and fluid therapy using ketanest. (Secondary): Furthermore, we hypothesise that adrenal gland is not suppressed…
We hypothesize that peripheral insulin sensitivity increases after a period of intermittent fasting because of an increased turnover of IMCL and/or subsequent changes in the composition of intramyocellular lipids (glyco(shpingo)lipids and…
Based on the type of cognitive impairments frequently observed in children with frontal lobe epilepsy, functional networks in the frontal and/or temporal lobe are expected to be disrupted. Therefore we expect neuronal reorganisation especially in…
We hypothesize that that single neuron recordings from depth micro-electrodes in candidates for epilepsy surgery can be used to reconstruct brain networks, and to determine the impact of epilepsy on these networks. This setup will allow us to…
1. A mindfulness-based psychological intervention (MBSR) will increase the emotional well-being and quality of life of patients with type 2 diabetes; 2. MBSR will improve self-care behavior; 3. MBSR will have a positive effect on blood pressure and…
This pilot study hypothesizes that folate-FITC enhanced fluorescence imaging enables the intra-operative detection of breast carcinoma in breast cancer patients.
The hypothesis to be tested in the phase II part is that arm B is feasible. The hypothesis to be tested in the phase III part is that the outcome in arm B is better than in arm A.
Care supported by case management and diabetes management for diabetics with comorbidity is perceived as better coordinated than care supported by disease management only.
To study whether dynamic MRI can predict treatment response and long term outcome in patients with Crohn’s disease.
Sentinel lymph node detection with fluorescent probes.
The aims of the present study are: 1. To give a comprehensive description of 200 adults (> 18 yr) with recently diagnosed adult-onset asthma (< 1 yr); 2. To define clinical, lung function or inflammatory or mixed phenotypes of adult…
In daily practice there are many treatment modalities for hemorrhoids available. Since many years the rubberband ligation is widly used. Recently there are also positive results reported of the artery ligation procedure. This research aims to…
Physiotherapy treatment is effective and cost-effective in patients who recently experienced a COPD exacerbation by reducing the frequency, duration and severity of following exacerbations. In addition, it will improve the functional health status…
It is hypothesized that treatment with B cell directed therapy in the pre-clinical phase of RA will decrease the development of arthritis.
In this study we compare in patients with advanced NSCLS a platinum contaiing chemotherapy regimen with a prolonged dose-intensified regimen with docetaxel that appeared to be less toxic.