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We hypothesize that by using different imaging techniques, we can give a good characterization of the bone marrow microenvironment in advanced-stage myelofibrosis, before and during treatment with ruxolitinib.
With implementation of the AWR we expect a reduction in the total amount of radiographs requested, without missing any clinical relevant fractures. We also expect a reduction in overall waiting times at the ED and a total amount of cost savings…
Fatigue affects central nervous system function and, in the setting of the medical profession, could influence specialist performance, patient care and safety. ln contrast to other industries, for example the aviation industry, there are no "…
About 10-15% of the population suffers from chronic insomnia. Structurally poor sleep can have unpleasant consequences for people's health and quality of life. Therefore, proper treatments are of great importance. Fortunately, Cognitive…
The self-help intervention Happy@Work will reduce symptoms of depression. The self-help intervention Happy@Work will be cost effective.
We hypothesize that peripheral perfusion targeted fluid management (PPTFM) might prevent excessive fluid administration, leading to less formation of tissue edema, less respiratory dysfunction and shorter duration of mechanical ventilation.
The purpose of the study is to conduct a randomised controlled trial with the onlinecourse 'Voluit Leven' as an intervention to study the: 1. Cost-effectiveness in terms of reduction of psychological symptoms (mood symptoms and disorders…
We want to establish an abbreviated, multidimensional, evidence based, diagnostic personalityprotocol within the mental health services. The hypothesis is that the mutidimensional testcombination of VTCI, NEO-FFI and CISS is sufficient reliable and…
A constant Hb concentration will improve the quality of life of patiënts with a chronic need for bloodtransfusions.
Interferons (IFNs) are a family of cytokines which have important antiviral and antiproliferative properties. They also play an important role in immunomodulation. Type I IFNs have been implicated in autoimmune diseases, including systemic lupus…
The primary objective of this study is to demonstrate that contact isolation of patients colonised with ESBL-producing Enterobacteriaceae in a multiple-occupancy room is not inferior to contact isolation in a single-occupancy room with respect to…
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The aims of this study are twofold: 1. Examine the effectiveness of the web-based CBT self-help intervention for MS-patients with depressive symptoms; 2. Compare characteristics of symptoms of depression and anxiety, quality of life and perceived…
The aim of this study is to investigate the effectiveness and the cost-effectiveness of the individual CBT program the “D(o)epressie cursus” by means of the following hypotheses; 1. Is the individual CBT program the “D(o)epressie cursus” more…
An educational film seen before surgery change the postoperative expressed need for opioids by the patient (i.e., increase when postoperative patients report NRS > 4 and decrease when patients report NRS ≤ 4).
Glucose control by closed loop in diabetes type 1 is equal to glucose control by insulin pump.
Delegation of clozapine monitoring tasks to a Nurse Practitioner (condition A) is at least as safe as Treatment As Usual: physicians perform monitoring tasks themselves (condition B).
To evaluate the impact of three different implementation strategies for implementing IBSM in current clinical practice, we have proposed the following three hypotheses: 1. Hypothesis 1 (Reach): More general practices will participate in IBSM in the…
The hypothesis to be tested is the feasibility of arm A and arm B.
1. Providing children with tailored non-smoking advice will prevent them from becoming a smoker; 2. Children receiving tailored non-smoking advice will have stronger cognitions in favour of non-smoking; 3. Prompting children through e-mail and SMS…