319 resultaten
Postoperative pain, further blood loss, onset of delirium and wound discharge are unfavorable factors that can prolong hospital time, delay mobilization and necessitate transfusion. Cryotherapy and pneumatic compression are suggested to minimize…
Several questions with respect to the routine use of medication reviews are not yet answered which hamper their large scale implementation. The Opti-Med study addresses these three problems. 1. A lack of evidence about the effectiveness of…
To evaluate the incidence, risk factors and perinatal morbidity and mortality due to CA after TTTS treated with fetoscopic laser surgery
The proposed study aims to investigate a novel peri-operative PK-guided dosing strategy, which is expected to reduce FVIII consumption and costs by minimally 25%. Moreover, the five participating hospitals will gain experience with PK-guided dosing…
Primary Objective: • Is CBM-I successful in changing the cognitive bias in patients with cluster-C personality disorders or personality disorder NOS? Secondary Objective(s): • Will patients following CBM-I show a significant reduction in symptoms…
Obesity is a growing world wide problem. In The Netherlands, about 10% of all men and women have a BMI of 30 kg/m2 or more. Obesity is a chronic, uncurable metabolic disorder, which is characterised by excessive fatstorage at unfavorable places.…
Since bleeding risk is high in the elderly we hypothesize that clopidogrel is superior to ticagrelor and prasugrel in terms of causing lesser bleeding events and being non inferior in net clinical benefit in patients above 75 years and CRUSADE…
Supplementation with omega-3 LCPUFA from krill oil in healthy adolescents will result in: - improvement of the omega-3 index - improved cognitive performance - improved mental well-being - better academic achievement
Child maltreatment is a major social problem with many adverse consequences. A substantial number of maltreated children is not identified by health care professionals. To improve identification of maltreated children in hospitals, a new hospital-…
To reduce treatment-related toxicity in patients with localized prostate cancer, focal treatment is warranted. This can be achieved with MRI guided high-dose-rate brachytherapy. We expect that a single dose of 19 Gy to the tumour volume will be of…
We expect that attentional bias is a possible moderator of the effects of food advertisement on food intake among children.
1. There is a medaiting effect of coping on the relation between preoperative stress and perioperative anxiety? 2. In comparison to no music there is a reinforcing influence of self-chosen music on the relation between ( emotion-focused) coping and…
The primary objective of this double blind study is to determine the effects of 1 mg, 4 mg, or 8 mg of ARA 290 administered subcutaneously for 28 consecutive days versus placebo on corneal nerve fiber density
VIDIO: Vitamin D Intensive Outreach includes a cholecalciferol loading dose, if applicable, and subsequent bimonthly high-dose cholecalciferol through an outreach approach of the Street Doctor Service in Rotterdam. CAU: Care As Usual includes daily…
Recent pre-clinical experiments demonstrated that sorafenib in Oatp1b2(-/-) mice had 8-fold increased sorafenib-glucuronide blood concentrations.OATP1B1 and 1B3 are highly expressed in the human liver and facilitate the hepatocellular uptake of…
The disease related intervention improves the psychosocial quality of life and self-efficacy of young adults with NF1.
The goal of this study is: 1) to adapt Video-feedback Intervention to promote Positive Parenting (VIPP) for parents of children with a visual impairment or visual-and-intellectual disabilities (VIPP-V), 2) to test the resulting program on its…
This study aims to clarify the hypothesized benefits of fast track surgery in the bariatric surgery population.
The primary objective of this study is to determine whether thrombectomy combined with ischemic postconditioning after PCI leads to a smaller myocardial infarction compared to standard therapy.
The purpose of this research is to acquire a better understanding of the pain experience and the recovery of children between 1.5 and 5 years old who underwent a tonsillectomy/adenotonsillectomy. Primary research question: What is the influence of…