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Total contact versus Total contact Softcast in treatment neuropathic plantar ulcers.

A TCS is comparable to TCC and an effective treatment in neuropathic forefoot ulcer,

Ik beweeg: Experiment 2.

An online motivational interviewing intervention which includes a virtual coach results into the higher levels of participation, evaluation and higher effects on intrinsic motivation, commitment and physical activity behaviour, compared to online…

Imaging Pelvic Organ Prolapse with up-right MRI

Pelvic organ prolapse (POP) is a common condition in middle aged and elderly women. Approximately 10% of women will have surgery for POP and/or urinary incontinence during their lifetime [3, 4]. POP can occur in the anterior, posterior or apical…

HospitalitY Project: Combining peer support and skills training ‘on the spot’

Rationale: Patients with a psychotic disorder are impaired on many aspects of social functioning and self-management. Consequently, social and emotional isolation is highly prevalent. Furthermore, clinic based (social) skills training tends not to…

Structure of variability in development

The physiological role of bile acid‐mediated glucagon‐like peptide‐1 release in humans: The Cerebrotendinous Xanthomatosis Mixed Meal Test study.

We hypothesize that CTX patients, when untreated for a short period, differ from matched healthy controls in the response to a test meal. CTX patients are expected to have lower postprandial GLP‐1 and insulin levels with higher plasma glucose and…

A prospective, open-label, multicenter randomized phase-II trial to evaluate the efficacy and safety of a sequential regimen of obinutuzumab (Gazyvaro) followed by obinutuzumab and venetoclax, followed by either standard venetoclax maintenance or MRD guided venetoclax maintenance in first-line patients with CLL and unfit for FCR-like regimens

Multiple ascending dose study with Memogain.

Extension of SAD PK/PD Model, confirmation of SAD PD effects

Vitamin D supplementation in type 2 Diabetes Mellitus.

Vitamin D supplementation will improve glycemic control in patients with type 2 diabetes melliuts.

Antibiotica voor de behandeling van acute blindedarmontsteking bij kinderen.

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A Post-Market, Open Observational Long-term Effectiveness Follow-up Study of Participants with Drug-resistant Epilepsy with Partial-onset Seizures previously Enrolled in a Randomized Controlled Trial (E-100: PuLsE) Comparing Best Medical Practice with or without Adjunctive Vagus Nerve Stimulation Therapy.

N/A

LEAK study

Surgical treatment (DAIR on day 10) will result in a 50% reduction rate of revision for PJI up to one year after primary TKA/THA compared to nonsurgical treatment. Consequently surgical treatment is more (cost) effective compared to nonsurgical…

Initial non-operative treatment versus direct operative treatment for simple appendicitis in children.

Initial non-operative treatment strategy is associated with as many or fewer complications, a better health-related QOL, reduced costs, and it avoids surgery in the majority of patients.

A phase I/II post-cord blood HCT dendritic cell vaccination trial directed against WT1 for pediatric acute myeloid leukemia: the U-DANCE-anti-AML trial

Cord Derived Dendritic Cell Vaccination directed against WT1 will prevent patients from relapse

Protocol implementation of Shared Decision Making in Dutch breast cancer care; a prospective process evaluation

Integrale Overactieve Blaas Clinical Trial in de klinische praktijk III.

1. SNS is more effective than BOTOX® 100 U as assessed by the difference between treatment groups in the proportion of idiopathic OAB patients with a positive treatment response on the Patient Perception of Bladder Condition (PPBC) at Week 12…

Early Surgery versus optimal Current step-up prActice for chronic PancrEatitis.

We hypothesis that early surgical intervention results in less pain over the study period and is more cost-effective than the optimal current step-up practice.

Development of the Nijmegen Decision Tool for chronic low back pain to guide patient triage and treatment.

The NDT-CLBP is a valid tool to guide treatment based on patient profiles for secondary spine care professionals

A method for non-invasive intracranial pressure measurement in glaucoma

The changes in DPOAEs from upright to 30 degrees HDT will be greatest for subjects who are expected to have the lowest ICP (primarily NTG subjects). Alternatively, the least amount of change in DPOAEs will occur in subjects who are expected to have…

The development of a medication-related patient-reported experience measure to better inform reimbursement decision making and clinical practice