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A preference trial with rizatriptan 10 mg and ibuprofen 400 mg in migraine patients in the general practice.

Patients prefer rizatriptan over ibuprofen for the acute treatment of migraine.

Treatment Intensification Based on Disease Activity Parameters or on Cartilage Breakdown Markers in Early Rheumatoid Arthritis.

In early RA, does treatment intensification (by conventional and biological means) aimed at keeping urine CTX-2 levels below 150 nmol/µmol creatinine lead to a lower radiological progression than treatment intensification aimed at keeping DAS28 at…

WOMB study.

1. Er is geen verschil in kwaliteit van leven wanneer er geen bloedtransfusie gegeven wordt bij een Hb daling van minimaal 1,2 mmol/l en/of een totaal bloedverlies van minimaal 1000ml en een 3,0 ≤ Hb ≤ 4,9 mmol/l indien er geen klachten zijn bij de…

Effect of treatment with an oral bisphosphonate on markers of bone formation and bone resorption in adults with alkpatonuria.

Treatment with a bisphosphonate leads to a decrease in the level of the marker of bone resoprtion in a periode of three months.

The efficacy of the combination of allergen vaccination and Vitamin D3 in the reduction of allergen-specific nasal responses. A placebo controlled trial.

Addition of subcutaneous vitamin D3 to subcutaneous allergen vaccination offers a superior protection to allergen-induced inflammation and obstruction, in comparison to allergen vaccination alone.

A randomized phase III study of chimeric anti-CD20 monoclonal antibody (Rituximab) with 2-weekly CHOP chemotherapy (CHOP 14) in elderly patients with intermediate- or high-risk non-Hodgkin’s lymphoma.

The hypothesis to be tested is that the outcome in arm B is better than in arm A.

MISSION! Intervention Study.

Thin strut cobalt chromium stents are not inferior in preventing restenosis compared to sirolimus-eluting stents in patients with acute myocardial infarction.

Participative ergonomics for mental health disorders, a randomised controlled trial and cost-effectiveness evalution.

Is participatory ergonomics for workers with common mental disorders more (cost-)effective on return-to-work than usual clinical medical care?

Molecular determinants of bone mineral density in children with acute lymphoblastic leukemia and the role of intervention by physical activities and calcium and vitamin D supplement as a preventive strategy.

Intervention with adequate calcium and vitamin D and physical activities will influence BMD and fracture rate in a positive way during and after treatment for childhood ALL.

Treatment-resistent depression in the elderly.

Both active medications are equally effective in the treatment of non-responding elderly patients but phenelzine is better tolerated than lithium.

The AIMS study.

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Randomized study on hemoglobin response in iron-deficient anemic patients with solid maglignancies receiving epoetin alfa (rHuEPO) in combination with either oral or parental iron supplementation during treatment with non-platinum containing chemotherapy.

To determine optimal route of iron supplementation during treatment with non-platinum containing chemotherapy for solid tumors.

A prospective (sero-)epidemiological study on contact transmission and chemoprophylaxis in leprosy.

Rifampicin is an effective chemoprophylactic intervention method to prevent leprosy among close contacts of leprosy patients.

Intensive back training protocol for low back pain.

The intensive group training protocol is a new intervention that combines exercise therapy with principles of back schools and behavioural therapy. We expect this new intervention to be superior compared to usual physiotherapy care.

Depression in chronically ill elderly.

MPI will reduce levels of depression and will increase their quality of life, while reducing health care-related costs in chronically ill elderly people with a depressed mood.

The effect of botuline toxin A in the subscapular muscle in stroke patients with shoulder complaints; a randomized controlled trial.

We assume that relaxation of the subscapular muscle will lead to pain reduction and improvement of mobility in stroke patients with shoulder- or armpain and limited range of motion of the shoulder.

Treatment of bone loss and changes in bone architecture in osteopenic patients with Crohn's disease; a comparison between calcium supplementation and vitamin D alone or combined with oral Risedronate 35 mg once weekly.

Bifosfornates in combination with vitamin D and Calcium is more effective that Vitamin D and Calcium alone for Crohn’s disease related osteopenia.

Computer tailored information to influence nutrition, smoking and exercise habits; testing the application at the community level.

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Double-blind randomised placebo-controlled cross-over study to investigate the safety and effectiveness of intrathecal glycine on pain and dystonia in Complex Regional Pain Syndrome type 1.

A large proportion of chronic patients with complex regional pain syndrome type 1 suffer from both neuropathic pain and dystonia. Findings from neurophysiological and intrathecal baclofen studies highlight an impaired inhibitory neurotransmission.…

Peripheral laserphotocoagulation in patients with bilateral drusen.

Peripheral laserphotocoagulation reduces drusen area in patients with bilateral drusen.