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A study to evaluate the different levels of attention and valence direction for erotic stimuli, in relation to genital and subjective sexual arousal in healthy female subjects and healthy female subjects with Female Sexual Dysfunction.

In the present placebo controlled study we will investigate the influence of valence on attention when viewing visual erotic stimuli. Especially when under the treatment condition of testosterone with sildenafil. In addition, we will investigate the…

Effects of crisis cards/plans for people with psychotic illnesses, facilitated through local patient organisation and through clinician, on the number of crisiscontacts with mental health services and the numer of (cumpulsory) admissions.

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Does booster influenza vaccination improve vaccination efficacy in patients with quiescent systemic lupus erythematosus?

SLE patients show a decreased humoral immune response to influenza vaccination, as compared to healthy controls. Furthermore the use of immunosuppressives is of influence on vaccination immunogenicity, it has been demonstrated that the use of drugs…

Radiotherapy with or without ibandronate in the treatment of painful bone metastases of prostate cancer.

The purpose of this study is to evaluate the efficacy of oral ibandronate (versus placebo) added to the standard radiotherapy regimen for painful bone metastases to reduce pain, to reduce the need of analgesics, and to reduce skeletal-related events…

Het HELIOS onderzoek naar behandeling van kinderen en adolescenten met ernstige obesitas.

Een klinisch behandelprogramma met een opnameduur van acht weken gevolgd door een intensief vervolgprogramma voor kinderen (8-19 jr.) met ernstige obesitas is kosten effectiever dan een klinische interventie met een opnameduur van zes maanden en…

Elastic stockings after varicose vein surgery: useful or nonsense.

Our hypothesis is that routine application of elastic stockings after varicose vein surgery is not beneficial with regard to pain- and physical functioning scores, complications, edema formation, time before returning to work and analgesics…

The effect of application of 0.12% chlorhexidine gel-toothpaste compared to 0.12% chlorhexidine mouthwash and regular toothpaste in a 3 day non-brushing model on plaque accumulation.

Tray application of 0.12% chlorhexidine gel-toothpaste has more than 15% better effect on ¡®de novo¡¯ plaque accumulation compared to tray application of regular toothpaste in a 3 day non-brushing model.

Treating Moroccan an Turkish migrants with depression and anxiety disorders (MIDA study).

Increasing the intercultural competence of mental health workers will reduce therapy dropout in Moroccan and Turkish patients with depressive and anxiety disorders.

Joint distraction in the treatment of knee osteoarthritis: efficacy and underlying mechanisms.

A two month distraction period results in similar clinical beneficial effects as a three month distraction period.

A Phase II multicenter study to assess the tolerability and efficacy of the addition of Bevacizumab to standard induction therapy in AML and high risk MDS above 60 years.

The hypothesis to be tested is that arm B is tolerable and that the outcome in arm B is better than in arm A.

Dyspepsia - Buspiron.

Development and introduction of a pediatric liquid formulation of
6-mercaptopurine for treatment of leukemia.

6MP treatment in pediatric ALL patients can be improved by developing a pediatric oral drinking solution of 6MP, assessing its bioequivalence, and -when successful- introducing the new formulation nationwide.

Prodromal symptoms and early intervention to prevent a relapse.

Could early treatment of prodromal symptoms prevent or postpone a psychotic relapse in schizophrenia?

Temperature during orthopedic surgery.

Obtain transient temperature data of the skin, core and wound surface during orthopedic back surgery in order to validate the numerical model of Severens for this type of surgery.

A Phase II randomized multicenter study to assess the efficacy of lenalidomide with or without erythropoietin and granulocyte-colony stimulating factor in patients with low and intermediate-1 risk myelodysplastic syndrome.

The hypothesis to be tested is that the outcome in arm B is better than in arm A.

Phase II trial of combination therapy with oxaliplatin and capecitabine in patients with advanced esophageal cancer.

For patients with metastatic or local-regional unresectable esophageal carcinoma there is no alternative treatment. In this trial it is studied whether combination chemotherapy with oxaliplatin and capecitabine prolongs survival and improves quality…

Posture or Patching (PoP).
Accelerated clearing of the media with massive vitreous hemorrhage and suspected retinal tear.

Binocular patching in combination with posture adherence is superior to posture adherence alone in achieving visualization of the superior fundus quadrants following a vitreous hemorrhage.

SC.20 / CKTO 2004-06
A phase III international randomised trial of singel versus multiple fractions for re-irradiation of painful bone metastases.

To study the effectivity of different retreatment radiotherapy schedules for painful bone metastases.

Comparison of the effectiveness and tolerability of different doses of intravenous glucocorticoid for the treatment of moderately severe Graves' ophthalmopathy. EUGOGO study C

The hypothesis is that cummulative doses of 2.5, 5.0 or 7.5 gram methylprednisolone infusions are equally effective in moderately severe Graves' ophthalmopathy, but that the doses differ in the number and severity of side effects.

Surgery versus stent for malignant gastro-duodenal obstruction.

To compare a surgical procedure (gastrojejunostomy, GJJ) with endoscopical stent placement in patients with malignant gastric outlet obstruction (GOO)