3040 resultaten
To date first line therapy in locoregionally advanced SCCHN consist of concurrent chemotherapy, i.e. cisplatin 100 mg/m² i.v d1,22,43, and radiotherapy. Therefore in recurrent and/or metastatic SCCHN treatment with cisplatin containing regimens…
urge incontinence is caused by overactivity of the detrusor muscle of the urinary bladder. Electrical stimulation of the pelvic floor muscles can suppress detrusor overactivity. The miniaturo tm-i system is designed to deliver mild electrical…
Comparison of two new techniques for detection of small bowel pathology: MR enteroclysis and videocapsule enteroscopy with double-balloon enteroscopy with respect to diagnostic yield, accuracy of findings, and patient preference.
HIV infected patients receiving HAART have an increased risk for cardiac events/disease. In HAART naive patients increased arterial stiffness is substrate for this higher risk. In this study we investigate whether increased risk for cardiac events…
Stress vulnerability as reflected by cortisolreceptor gene polymorphisms, influences course of bipolar disorder defined by number of episodes, physical health and cognitive functioning.
Folate supplementation improves microcirculatory function in subjects susceptible to microcirculatory dysfunction.
Bracing patients with adolescent idiopathic scoliosis in an early stage results in at least 5 degrees less mean progression of the curvature compared to the control group after two years of follow up.
By its pharmalogical action it is likely that aspirin improves ovarian perfusion, uterine perfusion and reduces endometrial restraint on the implanting embryo. Therefore the hypothesis of this study is that the use of low dose aspirin in IVF…
Before we focus our research on TMS-EEG experiments in epilepsy patients, we first aim to learn more about the characteristics and intra-subject variability of the TMS-EEG and MEP response in healthy subjects. In addition, we will evaluate if TMS-…
1. The training program will result in improved stability of walking; 2. The training program will result in improved rate of bone turnover (indicative of improvement in bone mass).
Accumulating data from both patients and animal models indicates that imbalances in the composition of the gut microbiota are related to obesity and its associated diseases However, the exact role of the microbiota and the mechanism mediating its…
In this study the hypothesis will be tested that gemcitabine has a radiosensitizing effect in addition to 131I-MIBG therapy which will lead to increased anti-tumour effect in neuroblastoma.
Major depressive disorder (MDD) is projected to rank second on a list of 15 major diseases in terms of burden and is highly recurrent in nature. Accordingly, efforts to reduce the disabling effects of this chronic condition should shift to…
In this study we will investigate the progression of IF/TA in protocol biopsies in a cohort of renal transplants, with a steroid sparing TAC-based immunosuppressive regimen in combination with either sirolimus (SRL) or mycophenolate mofetil (MMF),…
31-3-2014 Hypothesis: Early administration of 5 mg of Metoprolol is associated with a relative 20% reduction in infarct size as measured by cardiac Troponin-T, a total of 408 patients will be enrolled and randomized. Interventions: 5 mg intravenous…
The pain reductive effect of a neurectomy of the ilio-inguinal, ilio-hypogastric or/ and genital branch of the genito-femoral nerve(s) is significantly more compared to an injection with lidocain, corticosteroids and hyaluronic acid for neuropathic…
Testing for thrombophilia after a first episode of VTE with subsequent prolongation of anticoagulant treatment in thrombophilic patients is beneficial in terms of clinical outcomes, quality of life, and costs.
To assess the tolerability and efficacy of the addition of oral lenalidomide to standard induction therapy.
To evaluate variations of androgenicity and androgen (re) activity in (apparently) eugonadal women by using CAG repeat length polymorphism ([CAG]n) of the androgen receptor, free testosterone levels, 2D:4D ratio and attention for erotic stimuli (…
Social skills training will increase the social and communicative skills in daily life situations of children with ASDs as compared to children who do not follow such training. Additionally, training parents and teachers will increase generalisation…