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A Phase II multicenter study to assess the tolerability and efficacy of the addition of Bevacizumab to standard induction therapy in AML and high risk MDS above 60 years.

The hypothesis to be tested is that arm B is tolerable and that the outcome in arm B is better than in arm A.

Temperature during orthopedic surgery.

Obtain transient temperature data of the skin, core and wound surface during orthopedic back surgery in order to validate the numerical model of Severens for this type of surgery.

ETMI vs. standard video endoscopy for the detection of early neoplasia in patients with low-grade dysplasia in a Barrett's esophagus: a multi-center randomized cross-over controlled study

ETMI increases the detection rate of early neoplasia in BE patients with 40% or more compared to standard video endoscopy

The effectiveness of using plantar pressure assessment and monitoring in prescription footwear to reduce re-ulceration rate in diabetic patients: A Randomized Controlled Trial.

Therapeutic footwear of which adequate off-loading properties are guaranteed and monitored by dynamic plantar pressure assessment will result in a reduced plantar re-ulceration rate in diabetic patients with prior plantar foot ulceration compared to…

Efectiveness of adding 'exposure in vivo' techniques to the return-to-work plan of workers with mental health problems: a cluster randomised controlled trial.

Occupational rehabilitation with a gradual return to work based on the principles of exposure in vivo will be more (cost)effective in reducing absenteeism than usual occupational rehabilitation.

Diagnosis of cystic fibrosis fat malabsorption: fat absorption test.

The double labeled triglyceride and free fatty acid fat absorption test is as effective as the fecal fat balance as a quantitative diagnostic test for intestinal fat absorption in CF patients.

Small scale living facilities for older people with dementia.

It is hypothesized that residents in small scale living facilities, compared to those in regular nursing home care, have a higher quality of life and functioning. In addition, it is hypothesized that their family caregivers experience less burden…

Laparoscopic ileocolic resection versus infliximab treatment of recurrent distal ileitis in Crohn's disease: a randomized multicenter trial (LIR!C-trial).

Laparoscopic ileocolic resection may be more effective than infliximab treatment in recurrent Crohn´s disease located in the terminal ileum improving quality of life and reducing costs.

Observational Study;
Midazolam as CYP3A phenotyping probe
to investigate the effects of lapatinib
on hepatic CYP3A activity.

Lapatinib inhibits the function of Cytochrome P450 3A isoforms and P glycoprotein.

Contrast enhanced ultrasound imaging to support prostate cancer brachytherapy treatment and follow up after treatment.

Brachytherapy is globally used as a primary treatment for prostate cancer. The advantage of brachytherapy is that the radiation dose on healthy organs can be limited. Because prostate cancer is a multifocal disease the whole prostate has to be…

Observational study;
Pilot study assessing sildenafil effect on lung tumour blood flow.

Does sildenafil improve tumour perfusion?

Forlax versus Transipeg in constipated children.

Forlax and transipeg are equally effective in treating childhood constipation.

Dexamethasone for Cardiac Surgery study

A single, prophylactic dose of dexamethasone during cardiac surgery reduces the incidence of major postoperative complications.

A randomized, double blind, placebo-controlled trial to evaluate the clinical efficacy and the structure modifying properties of etanercept 50/25 mg sc weekly in patients with erosive OA of the interphalangeal finger joints.

Etanercept is able to improve clinical and functional abnormalities and to halt or reverse radiographic changes in inflammatory erosive hand osteoarthritis by virtue of blocking a major pro-inflammatory cytokine, tumor necrosis factor (TNF).

Diagnostic Study;
Contrast enhanced Magnetic Resonance Imaging of the lungs in children with CF.

We hypothesize that with Gd-MRI inhomogeneity of lung perfusion can be readily identified and that these areas match areas of trapped air as visualized by proton MRI and CT.

The effects of an exercise program on insulin sensitivity and plasma glucose levels in women at high risk for gestational diabetes.

Increasing levels of physical activity during pregnancy may be an effective strategy for the prevention of GDM.

Shared care for patients with chronic kidney disease in nephrology and general practice.

The hypothesis is that patients with chronic kidney disease will meet treating goals better when they are treated in a shared care model by a general practitioner, a practice nurse and with online consultation of a nephrologist.

Implementation of Colorectal Cancer Screening with FOBT in the Netherlands.

Implementation of Colorectal Cancer Screening with FOBT in the Netherlands is feasible

Postoperative flow prediction after creation of a vasculair access for hemodialysis with the aid of a computer simulation model.

It is generally accepted that the early-postoperative flow increase is indicative for successful maturation of an autologous arteriovenous fistula. Our hypothesis is that a patient-specific computer simulation model should be able to predict this…

Intraneural Injection in local anesthetic blocks and nerve damage.

Intraneural injection of anesthetics in upper and lower extremity blocks increases the risk of neurological damage.