391 resultaten
1. We expect that the PAED will be at least as reliable to diagnose a pediatric delirium, compared to the pCAM-ICU; 2. By combining the PAED, Comfort and SOS-score and pCAM-ICU for the diagnosis of pediatric delirium on the PICU, the critical care…
It is hypothesised that a loading dose of 150,000 IU cholecalciferol and of 300,000 IU are both effective in normalizing serum 25-OHD in insufficient en deficient individuals, but also in elevating serum 25-OHD in elderly with sufficient serum 25-…
High free fatty acids lower central serotonergic responsivity.
To assess whether the NOPHO- AML 2004 protocol can be used for the treatment of Dutch and Belgian children with newly diagnosed AML, whereby the cumulative dose of the possible cardiotoxic cytostatic antracyclines is lowered without increasing the…
Acute normovolemic hemodilution during coronary artery bypass surgery involving normothermic cardiopulmonary bypass (CPB) leads to dysfunction of cerebral autoregulation and therefore contributes to neurological morbidity after cardiac surgery.
In this study it is hypothesised that the inhibitory pain mechanisms DNIC and offset analgesia are affected in chronic pain patients compared to healthy controls. Furthermore it is hypothesised that ketamine has a improving effect on these pain…
Zevalin consolidation after first line therapy with R-CVP in patients with follicular lymphoma grade 1-3a, stage 2-4 induces conversion of PET positive PR to CR in more than 40% of patients.
We hypothesize that that single neuron recordings from depth micro-electrodes in candidates for epilepsy surgery can be used to reconstruct brain networks, and to determine the impact of epilepsy on these networks. This setup will allow us to…
A social network intervention (‘Powerful Together with Diabetes’) will enable diabetic patients in lower socioeconomic groups to effectively manage their type 2 diabetes and optimize their metabolic control, health related outcomes, diabetes…
Objective: 1. To determine protein balance in septic, critically ill children at baseline and during a Hyperinsulinemic Euglycemic Clamp, while receiving standard or high protein intake based on age group; 2. To assess insulin sensitivity and…
This pilot study hypothesizes that folate-FITC enhanced fluorescence imaging enables the intra-operative detection of breast carcinoma in breast cancer patients.
The hypothesis to be tested in the phase II part is that arm B is feasible. The hypothesis to be tested in the phase III part is that the outcome in arm B is better than in arm A.
Care supported by case management and diabetes management for diabetics with comorbidity is perceived as better coordinated than care supported by disease management only.
In daily practice there are many treatment modalities for hemorrhoids available. Since many years the rubberband ligation is widly used. Recently there are also positive results reported of the artery ligation procedure. This research aims to…
Physiotherapy treatment is effective and cost-effective in patients who recently experienced a COPD exacerbation by reducing the frequency, duration and severity of following exacerbations. In addition, it will improve the functional health status…
Post-pyloric feeding is frequently required in both critically ill and non-critically ill patients. Duodenal feeding tubes can be placed blind, under fluoscopy or by endoscopy. Migration rates of duodenal tubes are high. By clip-assisted placement…
The aim of this study is to develop and evaluate a patient-oriented treatment decision aid (PTDA) focussing on shared goal-setting and decision making, which is tailored to the needs and capacities of a heterogeneous group of patients with type 2…
The central hypothesis of this proposal is that statin therapy when added to chronic ARB treatment reduces sympathetic activity. Importantly, we study the addition to ARB therapy, because that mirrors everyday clinical practice.
Chronic use of anti-epileptic drugs is associated with low bone mineral density. However, not for all anti-epileptic drugs this associatjon has been found. To determine the prevalence of osteopenia and osteoporosis all adult patients with epilepsy…