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ANTIBIOTIC EXPOSURE AT THE INFECTION SITE IN PERIPROSTHETIC JOINT INFECTIONS

The overall aim of this proposed study is to gain insight into the target attainment of the administered antibiotics during the two-stage arthroplasty exchange, in order to determine the efficacy in relation to the minimal inhibitory concentration (…

FLOW

We expect that the access-related intervention rate and medical costs will be reduced by 40% when correction of vascular access stenosis is triggered by clinically apparent access dysfunction rather than by asymptomatic flow reduction detected by…

Short-term, manualized schema-focused group therapy within primary care for patients suffering from personality disorders at a high level of functioning

It is hypothesized that in a primary health care population, a more condensed form of schema therapy (ST) might be sufficient for an effective reduction of personality problems.

ProtEE study

The course of resting energy expenditure (REE), measured by indirect calorimetry changes based on standard versus high enteral protein feeding in the ICU.

Prospective Case Series of Acute Complex Wounds Treated With Glyaderm

Acute complex skin defects will heal using a dermal substitute (Glyaderm).

PowerSpiral Enteroscopy: Multicenter Prospective Study on Performance and Safety Including Patients With Altered Gastrointestinal Anatomy

Powerspiral enteroscopy provides an effective endoscopic procedure. Total small-bowel enteroscopy can be achieved, in one or two sessions, even in the presence of altered gastro-intestinal anatomy. It provides a great reduction of the enteroscopy…

Hemodynamic Cardiac Profiler for Assessment of Acute Hemodynamic Changes in Heart Failure Patients Undergoing Cardiac Resynchronization Therapy

We hypothesise that HCP provides reproducible and accurate measurements of LV volume changes during different CRT pacing settings which are comparable with invasive conductance catheter measurements.

Group Schema Therapy for the Other Specified Personality Disorder: a pilot study.

The hypothesis is that patients who complete the 30-weeks group schema therapy will benefit from this treatment (i.e., a significant drop in severity in the manifestation of OSPD, as measured with ADP-IV, and secondary outcomes) at Post-Booster and…

De-implementation of URInary catheters in Neurosurgical patients during the operation and on the ward

By reducing the number of inserted indwelling urinary catheters, urinary tract infections will be reduced which in turn reduces hospital stay and increases patient' comfort

Prospective multicenter observational cohort to assess quality of life, cost-effectivity and functional outcomes following minimal invasive surgical techniques for rectal cancer in ‘dedicated centers’

QoL, CE and functional outcomes differ significantly between L-TME, R-TME and TaTME.

Taste function after chorda tympani injury

Sacrificing the chorda tympani causes less taste disfunction than stretching or damaging the chorda tympani nerve.

Beter Samen Beslissen

We hypothesize that clinicians exposed to this intervention are more likely to adopt SDM behaviors than clinicians who do not. A secondary aim is to evaluate whether patients perceive more involvement in the decision-making process.

Predicting and Understanding Depression Prevention Techniques: a mechanistic cross-over trial of mindfulness vs. fantasizing to reduce vulnerability for depression

I. Test whether psychological and psychophysiological indices of PC are differentially affected by fantasizing vs. mindfulness in remitted MDD patients and HC: Pre-and peri-intervention changes will be examined using within-subject and between-group…

Clinical relevance of Clinician and Patient Reported Outcome Measures in patients with upper extremity injuries by determining Minimal Important Change (COMIC)

The aims of this study are validation of PROMs and estimating the minimal important change (MIC) for PROMs and CROs.

On TRACk: a blended intervention incorporating TRaining, prepAration and Counseling to improve inhaler technique and medication adherence in patients with a chronic lung disease

On TRACk, a blended intervention that prepares both patients and pharmacy technicians for two inhaler medication consultations and trains technicians in their communication will improve inhaler medication adherence and inhaler technique in patients…

A Phase I-II study of virus neutralizing antibodies against SARS-CoV-2. A focus on convalescent plasma and hyperimmune anti-SARS-CoV2 immunoglobulines

Primary Objective: • To create a population pharmacokinetic model of SARS-COV-2 neutralizing antibodies as present in ConvP. • To create a population pharmacokinetic model of SARS-COV-2 neutralizing antibodies as present in Nanogam plus Secondary…

Detection of neonatal sepsis with non-invasive transcutaneous blood gas monitoring

Transcutaneous blood gas measurements can be used to detect neonatal sepsis.

“I’m only fit when my smartwatch says so”: When does the use of health tracking technologies lead to bodily empowerment or bodily alienation?

We expect that STRAVA users who will stop with using the self-tracker will experience body empowerment, while people who are using no self-tracker and will start using STRAVA will experience body alienation.

Pure fruit juice, fruit, sugar-sweetened beverages and asthma

Sugar-sweetened beverages (SSBs) have been associated with a higher risk of asthma and are popular among children and adolescents, while fruit consumption have been associated with a lower risk of asthma. The sugar content of pure fruit juice is…

ECAP Guided SCS Lead Implantation: an interventional feasibility study

This could potentially improve the speed and accuracy of the operation to implant the epidural leads and make the procedure more comfortable for the patient