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LDL cholesterol in zeer hoog risico patiënten

PENELOPE onderzoekt welk cohort van een sub-populatie hoog risico patiënten na een Acuut Coronaire Syndroom (ACS) bij het strikt volgen van de richtlijn in drie stappen niet de beoogde lipide streefwaarden behaalt. De studie volgt de reguliere…

Hand instruments are better accepted than rotary instrumentation for restoring tooth cavities in people with disabilities.

The ART approach is more suitable than conventional restorative treatment in people with disabilities

Prospective Assessment of Risk Factors for Appropriate ICD Intervention in Patients with Ischemic Cardiomyopathy.

The primary alternative hypothesis states that the mean relative infarct transmurality (RIT) is different in patients with (RITshock or ATP ) and without appropriate ICD intervention, i.e. shock or ATP.

Exploratory study to investigate the effects of a new infant formula in healthy term infants during the first 6 months of life.

That the combination of two known immunologically active ingredients can effectively modulate the intestinal microbiota and immune system and thereby might reduce the incidence of allergy and infections.

Corticosteroid injections in patients with trochanteric pain syndrome: open label randomized clinical trial in general practice.

Local corticosteroid injections combined with usual care will have a positive effect on experienced recovery and will reduce pain at 3 and 12 months follow up compared to usual care alone.

IMPROVED: Induction therapy with Methotrexate and Prednisone in Rheumatoid Or Very Early arthritic Disease.

There is a clinically and statistically significant difference in the percentage of patients who achieve and maintain clinical remission (defined as DAS < 1.6) and in functional ability and progression of radiological joint damage after 1…

The influence of psychological factors on the onset and course of Complex Regional Pain Syndrome Type I.

Psychological factors (e.g. personality style) influence the course of CRPS-I but not the onset of this syndrome.

Immediate implant placement in molar extraction sites; a 5-year prospective case series pilot study

not applicable

Therapeutic Drug Monitoring in HIV-Infected Children Starting a New Anti-Retroviral Regime.

The effect of the TDM strategies on the viral load in terms of change from baseline (start or switch of therapy) to 96 weeks.

Problem Solving Treatment (PST) Project.

There is a need for assistance by primary care mental health workers in general practice in the Netherlands. General Practitioners (GPs) experience an overload of frequent attenders suffering from (co-morbid) psychological problems. For most GPs…

Effects and evaluation of a multifaceted intervention program to increase influenza uptake among health care workers (HCWS) in nursing homes.

A multifaceted intervention program on influenza vaccination among HCWs in nursing homes, based based on results of a previous study, is more effective in increasing vaccination uptake than the usual programs.

A pilot, open-label, multi-centre study to investigate the safety of Calf Intestinal Alkaline Phosphatase in patients with fulminant active ulcerative colitis refractory to steroid therapy.

Ulcerative colitis is characterized by abnormal activation of the colon epithelium, which is considered to be a central pathogenic mechanism. Activation of colon epithelium cells in UC is associated with an abnormal high expression of Toll-like…

Study of gut microbiota profile in children with propionic acidemia

NA

Study to describe the processing of ropivacaine in the body when injected in the knee for pain treatment in total knee replacement surgery

The objective of this study is to describe a pharmacokinetic profile of total and unbound plasma concentrations ropivacaine, when used for local infiltration analgesia in total knee arthroplasty

The NOICH Study.

The hypothesis is that 0.5 g/kg/wk of IvIG is as effective as 1.0 g/kg/wk, in the prevention of ICH in FNAIT.

Feasibility and Efficacy of dose adjusted Melphalan ¨C Prednisone ¨C Bortezomib (MPV) in elderly patients >= 75 years of age with newly diagnosed Multiple Myeloma; a non-randomised phase II study

This study aims to assess the feasibility of a dose-adjusted MPV scheme in patients >= 75 years of age and to assess the value of geriatric assessments to predict both feasibility and efficacy.

Rustmetabolisme in kinderen met kanker

REE zal gemeten worden middels indirecte calorimetrie. Zuurstofverbruik (VO2) en koolstofdioxide productie (VCO2) worden gemeten. De respiratoire quotient (RQ) zal verkregen worden uit de VO2 e n VCO2.  Lichaamssamenstelling zal…

The effect of specialized nutritional intervention with a disease-specific sip feed (Cubitan) in the support of patients with pressure ulcers.

Improving the rate stage III/IV pressure ulcers heal through nutritional support.

Aerobic Muscle Capacity in PPS.

Research questions and accompanying hypotheses: 1. Is there a difference in fatigue resistance of the knee extensor muscles between patients with PPS and able-bodied control subjects and is this related to aerobic capacity? Hypothesis: It is…

Evaluation of the mucosa-permeability of the stomach measured by the Ussing Chambers technique in patients with functional dyspepsia before and after treatment with amitriptyline.

Through stress the mast cells become activated and by their vaso-active substances the mucosa permeability will become increased. Therefore the mucosa is easier to penetrated by microbes and acid. This increased permeability will leads to…