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Effect of Computer-Controlled Cooling on Surgical Aspects after a Displaced Intra-Articular Calcaneal Fracture (Cool-DIACF); A Multicenter Randomized Controlled Trial

We expect that preoperative and postoperative cooling will reduce swelling faster, reducing the time to surgery and time to discharge, respectively.

Urological complications after live donor kidney transplantation: Intravesical or extravesical ureterovesical anastomosis?

Our hypothesis is that the extravesical technique reduces the incidence of PCN placement, and urological complications.

EMG registration in chidhood asthma

An increase of diaphragmatic and accessory breathing muscle activity is an indicator for the severity of childhood asthma.

Stapler or endoloop closure of the appendiceal stump in laparoscopic appendectomy.

Superficial and intra-abdominal infections: 8% in the standard loop group to 4% in the endoloop closure group.

Lithium trial in ALS

Lithium has important neuroprotective properties involving mechanisms that may play a role in the pathogenesis of ALS. In addition, lithium significantly prolonged the disease duration in the animal model for ALS, the SOD1 transgenic mouse as also…

Effectiveness of a Minimal Intervention Strategy for patients with common mental disorders on sick leave: a pragmatic randomized controlled trial in General Practice.

The objective of this study is to assess the effectiveness of the minimal intervention package (MISS) for distressed patients in general practice.

Costs and effects of strategies to prevent oversedation in Intensive Care patients.

Objective: To compare patient safety, inversely estimated as the duration of ICU stay, and costs between three groups of patients: 1. Those in whom sedatives will be administered continuously and in whom sedation level will be monitored clinically…

TIP-glucocorticoids research UMCU rheumatology; Cardiovascular risk factors and insulin resistency in reumatoid arthritis patients with and without glucocorticoids.

What is the relation between disease activity, treatment, and metabolic syndrome / insulin resistance.

THE GLOBAL RANDOMIZED NBI BLADDER CANCER STUDY -A Multi- Centre, International study to compare use of Narrow Band Imaging (NBI) versus White light (WL) during TURB to assess recurrence of bladder cancer in terms of safety and efficacy.

To compare the recurrence rate at 1 year following Narrow Band Imaging and TURB (Arm A) with White Light Trans Urethral Resection of Bladder cancer (TURB) (Arm B) in patients with non muscle invasive (NMIBC Ta/T1) bladder cancer.

(Functional) Magnetic Resonance Imaging of the brain in patients with tinnitus.

The underlying mechanism of tinnitus is tonotopic reorganisation of subcortical auditory areas.

Effects of a nurse coordinated program of lifestyle interventions aimed at reducing the risk of recurrent events in patients who have suffered a heart attack.

A comprehensive multisiciplinary lifestyle intervention program reduces the risk of recurrent cardiovascular events in patients who have suffered an acute coronary syndrome.

Social Network Analysis of Risk behavior in Early adolescence (SNARE) Genetics

This study examines the interplay between adolescents’ peer relations and molecular genetics in predicting risk behaviors. The central question is: How do molecular genetic information and peer dynamics interplay in explaining adolescent risk…

Cognitive behaviour therapy versus Self-examination therapy with depressive symptomatology.

Cognitive behaviour therapy and Self-examination therapy are both more effective in reducing depressive complaints than a waiting list control group.

Mild depression in primary care: do antidepressants add any effect to usual consultations?

Antidepressant medication does not add any effect to usual consultations by general practitioners in patients with minor and mild-major depression.

Study to look after defects of the cesarean section scar with ultrasound and study for risk factors to develop a defect.

Scar defect may give complications on long term. Study is to investigate if the defect is detectable with ultrasound.

The effect of glycopyrroniumbromide on hypersalivation in patients with Parkinson's disease: a randomised, cross-over, doubleblind, placebocontrolled trial.

The aim of this study is to prove the efficacy of 3 times daily 1 mg glycopyrronium bromide admixture versus placebo admixture in patients with PD with hypersalivation. Furthermore, the safety of glycopyrronium bromide used in the mentioned dosage…

Safety and efficacy of human lactoferrin hLF1-11 for the treatment of infectious complications among haematopoietic stem cell transplant recipients.

A peptide representing the first eleven residues of hLF (hLF1-11) was shown to be effective in killing a variety of bacteria in vivo. The objective is to develop hLF1-11 as an effective and safe antibacterial and antifungal for the treatment of…

Influence of psychological factors on healthcare visits of patients with instability of the hand-wrist

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Effectiveness of Stay Cool Kids (Alles Kidzzz): An indicated preventive intervention for externalizing problem behavior in school age children.

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A study looking at 2-Iminobiotin as treatment for newborn children suffering from insufficient oxygen supply to the brain in addition to standard treatment with cooling.

To explore the short term safety and tolerability of 2-IB and the pharmacokinetic profile of 2-IB when given on top of therapeutic hypothermia