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Sentinel node Navigation surgery in early esophageal adenocarcinoma Patients

Sentinel node navigation surgery in early esophageal adenocarcinoma is feasible and safe.

Metabolic effects of morning light.

Type 2 diabetes is a major threat to human health. Disruption of the circadian timing system is associated with metabolic changes. Disturbance of the daily light and dark rhythm could contribute to this phenomenon and effects metabolic pathways. We…

EffeCTIve: Study of the effectiveness of Critical Time Intervention after residence in Dutch women’s shelters.

One of the main priorities of Dutch women’s shelters is to professionalize working methods in the care for abused women. Moreover, shelters are focused on evaluating outcomes of women’s trajectories. Until now most Dutch women’s shelters have not…

UP2-study

The hypothesis formulation for the primary outcome parameter is: - H0: The effect of using product A is unequal to the effect of using product B with respect to serum P AUC0-360 [mmol/L*min] in subjects with elevated gastric pH. - H1: The effect of…

The Role of microbial produced ethanol in etiology of non-alcoholic steatohepatitis

We hypothesize that subjects with NASH produce more ethanol after a mixed meal tolerance test than subjects with a healthy liver after receiving a infusion with fomepizole.

Solace European Confirmatory Trial.

The Solace European Confirmatory (SOLECT) Trial is designed to determine whether the Solace Bladder Control System is safe and effective for the treatment of Stress Urinary Incontinence (SUI) in adult females.

Comparison of different doses of levobupivacain for caudal block in children undergoing hypospadia repair.

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Home UVB phototherapy in psoriasis: Effectiveness, Quality of life and Cost-effectiveness.

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Prebiotic oligosaccharides and fermented formula study.

Adding prebiotics or ferments to infant formula may improve digestive comfort in infants. Therefore, the infant formula tested in this study, combining these ingredients, may contribute to improved digestive comfort. In this study it also has been…

Effect of an Enhanced PerOperative Care and Health Program

To evaluate the effect of an enhanced perioperative care program added on to usual care. It is hypothesized that the enhanced perioperative care and health protection (EPOCH) program added on to usual care reduces postoperative surgical site…

Prospective study on the effects of adalimumab treatment in
patients with rheumatoid arthritis.

To evaluate the response to adalimumab treatment in TNF-alpha blockade naïve patients and patients who failed prior other anti-TNF-alpha treatment and to understand the mechanisms underlying the clinical response to TNF-alpha blockade.

Effectiveness of adenoidectomy in children with recurrent upper respiratory tract infections.

This is a superiority trial testing the hypothesis that adenoidectomy is more effective than a watchful waiting strategy in children with recurrent upper respiratory tract infections.

Tolerance and safety study of a new paediatric peptide feed.

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Een fase I/II vaccinatie studie met patient eigen dendritische cellen geladen met TAT, REV en NEF mRNA in HIV geïnfecteerden tijdens stabiele HAART.

This study is designed to determine safety and toxicity of the administration of autologous DC electroporated with mRNA encoding the early expressed HIV-1 proteins Tat, Rev and Nef in patients who are virologically and immunologically responding to…

The Amsterdam Paediatric Wrist Rules

With implementation of the APWR we expect a reduction in the total amount of radiographs requested, without missing any clinical relevant fractures. We also expect a reduction in overall waiting times at the ED and a total amount of cost savings…

Randomized induction and post induction therapy in adult patients (= 1.5.

The 3 hypotheses to be tested are that the outcome in: 1. The high dose arm B is better than in the low dose arm A; 2. The G-CSF arm is better than in the non-G-CSF arm; 3. The PBSCT arm 2 is better than the chemotherapy cycle III arm 1.

The (cost-) effectiveness of an internet intervention for eating disorders.

1. The intervention is effective in reducing eating disorder symptoms; 2. There is an incremental effect of intensive/frequent support from a coach in terms of reducing ED symptoms.

Effect of thoracic epidural anesthesia (TEA) on right ventricular function and ventricular-pulmonary coupling.

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Treatment of Complex Regional Pain Syndrome type I; A randomised, single-blind, placebo-controlled study with multiple rounds of S(+)-ketamine infusions.

Multiple rounds of S(+)-ketamine infusions will give more profound and prolonged pain relief compared to a single infusion of S(+)-ketamine.

An open randomised study comparing efficacy of maintenance therapy with imiglucerase at a frequency of once every four weeks versus the original schedule (once every one or two weeks) in adult type I Gaucher disease patients.

To compare the efficacy of maintenance therapy with an equal monthly dose of imiglucerase when administered at a frequency of once every four weeks versus once every one or two weeks, in adult type I Gaucher disease patients in stable and good…