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'Clinical decision support in children with fever'. Impact of clinical decision support on paediatric emergency care.

Evidence based medicine is the standard for current clinical practice. Guidelines and decision rules are developed to support medical decision making. Application of decision rules are supposed to improve efficiency and quality of care by early…

Observational cohort of patients treated with stereotactic radiotherapy for Oligo LYMPh nOde and other soft tissue metastasiS; the OLYMPOS cohort

The main clinical challenge remains to identify patients who may benefit from aggressive local treatment (stereotactic radiotherapy, SBRT) of soft tissue oligometastases: for which patients can systemic treatment be postponed? Patients who are…

Prospective observational risk-analysis of the incidence and severity of pressure ulcers and wound infections in obese patients in the ICU.

Patients with a BMI > 30 kg/m2 in the ICU have a higher incidence of pressure ulcers and wound infections in the ICU compared with patients with a BMI 18-25kg/m2. They develop them sooner during admittance and the severity and time to…

A feasibility study to test if an intervention can improve shared decision-making in advanced Parkinson's disease

The study will address the feasibility of the shared decision-making (SDM) intervention by (1) analysing the acceptability of the intervention by users (i.e. professionals and patients); (2) assessing the level of implementation; (3) testing…

Prevention of Migraine in Adolescents.

Based on systematic reviews concerning effective treatments in children with migraine a medical treatment (propanolol) as well as a non-medical treatment (relaxation therapy) appear to be effective compared to no treatment or placebo. however their…

Effectiveness of infliximab (TNF-alpha antagonist) in the treatment of late-onset depressive spectrum disorder in patients of 60 years and above.

Aetiology of late-onset depressive spectrum disorders may be different from the aetiology of early-onset depression. Concordant with the supposed aetiology of dementia, it has been postulated that chronic low grade immune activation plays a role in…

Pulsatile II study.

Pulsatile flow during cardiopulmonary bypass (CPB) results in preservation of microcirculatory function in the early postoperative period as compared to non-pulsatile CPB.

Treatment of PTSD in children

The present study aims at the improvement of the treatment of children with PTSD by examining the effectiveness of a brief intensive exposure therapy (IET) for children with PTSD using a multiple baseline design (patients are randomly assigned to…

Efficacy of probiotics and selective decontamination of the digestive tract in reducing bacterial translocation in patients with pylorus preserving pancreaticoduodenectomy.

Perioperative administration of probiotics or SDD has an effect on small bowel bacterial overgrowth and bacterial translocation to lymph nodes in patients undergoing PPPD by protecting or enhancing bowel (mucosa) permeability.

Cocaine en creativiteit

It is expected that acute challenges with cocaine will induce two opposing effect on creativity. That is, cocaine will increase mood leading to enhancement in divergent but not in convergent thinking.

Study of alternative drug to insulin for the treatment of high blood glucose concentration in cardiac surgery patients

We hypothesize that liraglutide treatment, initiated before cardiac surgery, is effective in lowering the number of patients needing perioperative insulin adjustments and reducing the total amount of insulin needed in the perioperative period when…

Renal toxicity during cancer treatment with angiogenesis inhibitors

We hypothesize that podocyturia is an early marker of ongoing renal damage during angiogenesis inhibition.

Weight loss with protein and resistance exercise in overweight older adults

A high protein diet and resistance exercise have a positive effect on fat free mass, fat mass, muscle strength, physical functioning and quality of life compared to regular dietary and exercise advice according to CBO guidelines for treatment of…

Gerandomiseerde vergelijking tussen het gebruik van indocyanine groen, patent blauw en radioactiviteit en het gebruik van indocyanine groen en radioactiviteit bij intra-operatieve fluorescente beeldvorming van schildwachtklieren bij borstkankerpatienten.

ICG alone combined with radioactivity will perform better than ICG combined with patent blue and radioactivity.

Effects of two different GH doses in children with growth hormone deficiency

A higher GH dose leads to a higher adult height

Biomarkers van chronische ontstekingsziekten van de gewrichten.

The goal of this study is to identify and validate recently discovered and novel biomarkers of pathophysiology, diagnosis, classification, disease activity, prognosis, treatment susceptibility, and treatment efficacy in chronic inflammatory…

Self-management and congestive heart failure: a randomized controlled trial to improve health-behavior and health-related quality of life by increasing self-efficacy expectancies in congestive heart failure patients.

1. Self-efficacy expectancies may increase by the "Chronic Disease Self-Management Program" in congestive heart failure intervention patients as compared to controls; 2. These higher levels of self-efficacy expectancies contribute to…

The effectivenessof the Internet 'Self-Examination Therapy (SET)'on anxiety, depression and burn-out: a randomised trial.

The Internet 'Self-Examination Therapy' (SET) on anxiety, depression and burn-out wil be effective in reduction of complaints (depression, anxiety, burn-out).

Occurrence of signs and symptoms of pectus excavatum (PE) in seniors

Pectus excavatum may not be as harmless as generally assumed and may lead to symptoms like dyspnea or fatigue after exercise

Triptorelin Oral contraceptive Pill Flare-up in IVF/ICSI Treatment trial.

The aim of the study is to show non-inferiority of a short, flare-up GnRH-agonist protocol to the GnRH-antagonist protocol, both with OC pill pre-treatment, in women undergoing in vitro fertilisation (IVF) or intracellular sperm injection (ICSI)…