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Suicide Prevention by Monitoring and Collaborative Care

We hypothesize to attain a drop of 20% of completed suicides in Noord-Brabant, the Netherlands.

Efficacy of tibolone and raloxifene for the maintenance of skeletal muscle strength, bone mineral density, balance, body composition cognitive function, mood/depression, anxiety and quality of life / well-being in late postmenopausal women > 70 years: Study design of a randomized, double-blind, double-dummy, placebo-controlled, single-center trial

The primary aim is to determine if there is a difference between tibolone and placebo or if there is a difference between raloxifene and placebo. The secondary aim is to determine if there is a difference between tibolone and raloxifene. Primary…

Postoperatieve uitkomsten van pijn management bij operaties waarin een deel van de wervelkolom wordt vastgezet

Most patients undergoing spine surgery with pedicle screw instrumentation will experience insufficient pain relief in the first three days after surgery, whereafter postoperative pain can be managed with conventional, non-opioid analgesics in most…

Repetitive transcranial magnetic stimulation in the treatment of depression.

rTMS has a positive effect in the treatment of depression.

Migration of the NexGen Total Knee Prosthesis: A 4-arm RCT comparing.

Two year migration is comparable between all 4 groups.

Hysteroscopic removal of intra-uterine disorders. A comparative study of learning electrosurgical- versus mechanical techniques.

N/A

The effect of intraileal infusion of fat emulsions, differing in degree of saturation, on satiety and food intake after a liquid meal replacement.

Long-chain triglyceride (LCT) emulsions with di-unsaturated fatty acids will lead to enhanced postprandial satiety and reduced energy intake in a subsequent meal, as compared to LCT emulsions with mono-unsaturated or saturated fatty acids.

Efficacy and tolerability of ixazomib, daratumumab and low dose dexamethasone (IDd) followed by ixazomib and daratumumab maintenance therapy until progression for a maximum of 2 years in unfit and frail newly diagnosed multiple myeloma patients; an open-label phase II trial

This study aims to assess: - the efficacy of 9 cycles of ixazomib, daratumumab and low dose dexamethasone in newly diagnosed unfit and frail multiple myeloma patients. - the value of geriatric assessments to predict both feasibility and efficacy…

Electronic Recording of Compliance with Patching Therapy for Amblyopia.

Compliance with patching therapy for amblyopia can be improved by an educational programme aimed primarily at the child.

Cost-effectiveness of an injury prevention program in male amateur soccer: A cluster randomised controlled trial.

The hypothesis is that integrating the exercises of the “The11” in the warming up is beneficial regarding injury incidence, injury severity, corresponding medical costs and/or work absenteeism.

• Research study to investigate the safety, tolerability and effects of multiple doses of LTI-291 in patients with Parkinson’s Disease with a GBA1 mutation.

• To evaluate the safety and tolerability of three oral dose levels of LTI-291 following 28 days of LTI-291 treatment in patients with Parkinson’s Disease with GBA-PD. • To characterize the plasma and CSF pharmacokinetics (PK) of LTI-291 following…

The effects of parent training on behavior problems, ADHD-symptoms and parenting stress in children with ADHD in routine child psychiatric out-patient care.

1. Parent training will lead to a significant reduction of behavior problems in comparison with routine medical care; 2. Parent training will be as effective as routine medical care with respect to the reduction of ADHD-symptoms; 3. Parent training…

A study on the efficacy of the combination of growth hormone and gonadotropin releasing hormone analogues (GnRHa) on adult height in children with idiopathic short stature.

A combined treatment of GH and GnRHa for 3 years in short adolescents with relatively early puberty leads to final height gain.

Novel approaches in IVF.

Strategies involving shorter and milder ovarian stimulation protocols and single embryo transfer may allow for more IVF cycles in the same period of time, resulting in similar term live birth rate per treatment period despite a minor reduction in…

Drinking Less, Self help for Problem Drinking: randomised clinical trial.

To test the effectiveness of a self help booklet without therapist guidance vis-à-vis a psycho-education brochure for adult problem drinkers in the general population.

The validity and effectivity of the new checklist ‘Attune & Stimulate’ for parents and caregivers of persons with severe intellectual disabilities (SID).

1) The checklist 'Attune & Stimulate' is a valid instrument to assess the arousal level of clients with SID. 2) Caregivers who are randomized to the intervention group that is instructed to use the A&S-checklist attune…

Two-sample FIT-screening: a 4th screening round

Surgical treatment of midshaft clavicular fractures with dislocation: Plate fixation versus intramedullary fixation.

The null hypothesis of the primary outcome measure is that there will be no significant differences in DASH scores 6 months after surgery between patients who underwent plate fixation or intramedullary fixation with a TEN. The alternate hypothesis…

Effectiveness of currently available cardiac rehabilitation programmes from 8 European institutes in elderly patients.

Null hypothesis: the 8 centres with different cardiac rehabilitation (CR) programmes do not differ from each other with regards to the effectiveness.

Impact of COVID-19 on physical activity and lifestyle of school going adolescents of Punjab (ICPASA): Designing an evidence-based physical activity intervention in COVID era

The natural experiment of COVID-19 related governmental measures of home confinement and social distancing has led to a decrease in physical activity levels of school going adolescents of Punjab, India.