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Cardiac Effects of Thoracic Epidural Anesthesia in Clinical Conditions in Patients.

We aim to evaluate the effects of thoracic epidural analgesia on the heart function in human, both during general anaesthesia and mechanical ventilation during major abdominal or thoracic surgery or during one-lung ventilation.

MelanoMelanoScan: Detectie van recirculerende tumor-geassocieerde macrofagen en circulerende melanoomcellen als tool voor monitoring in melanoom patienten: een pilot studieScan

MelanoScan

Physical counterpressure manoeuvre trial.

In patients with syncope and and absence of significant structural heart disease physical counterpressure manoeuvres decrease the total syncope burden compared to standardized intensive conventional therapy.

PORTEC-2: Postoperative Radiation Therapy for Endometrial Carcinoma – a multicenter randomised phase III trial comparing external beam radiation and vaginal brachytherapy.

Vaginal brachytherapy, as compared to external beam pelvic radiotherapy, will provide equal 5-year vaginal control and overall survival, with less treatment related morbidity and better quality of life.

ABC-trial.

Primary: Additional treatment with antibiotics in case of an exacerbation of COPD will not lead to a reduction in the severity and duration of exacerbations compared to treatment without antibiotics; Secondary: The relapse rate (defined as a new…

Use of NIRS during mechanical thrombectomy for ischaemic stroke

The NIRS monitor is capable of detecting changes in cerebral oxygenation

Lycopene and Vitamin E in men with minimal prostate cancer and rising PSA after radical prostatectomy. A double blind randomised placebo controlled cross-over study.

A combination of Lycopene and Vitamin E decreases PSA progression.

Problem Solving Treatment (PST) Project.

There is a need for assistance by primary care mental health workers in general practice in the Netherlands. General Practitioners (GPs) experience an overload of frequent attenders suffering from (co-morbid) psychological problems. For most GPs…

Effects and evaluation of a multifaceted intervention program to increase influenza uptake among health care workers (HCWS) in nursing homes.

A multifaceted intervention program on influenza vaccination among HCWs in nursing homes, based based on results of a previous study, is more effective in increasing vaccination uptake than the usual programs.

A Randomized Trial comparing Surveillance with Radio-Frequency Ablation of Barrett’s Esophagus with Low-Grade Dysplasia; the SURF-study.

Radiofrequency ablation (RFA) will lead to permanent and complete eradication of Barrett's epithelium. This will prevent development of high grade intraepithelial neoplasia (HGIN) or early carcinoma and may eliminate the need for endoscopic…

SUstainable PREvention of cardioMEtabolic risk through NUDGing hEalth behaviors

Changing the context in which individuals make lifestyle choices has a sustained impact on the dietary intake and cardiometabolic health.

Prevention of Depression and Anxiety in Adolescents with a High Familial Risk.

The effectiveness of an indicated indicated depression and anxiety prevention program ('Een Sprong Vooruit') will be tested in a Dutch sample of adolescents (aged 11-15) with high familial risk. It is expected that the adolescents who…

Information processing, neuropsychological, and neurobiological processes in pediatric obsessive-compulsive disorder.

Information-processing: 1. Changes in measures of severity of OCD are explained (partially) by changes in measures of meta-cognitions (explicit and/or implicit); 2. Changes in measures of meta-cognitions (explicit and implicit) precede changes in…

Thuis in de opvang: Een fijne start voor baby’s

The intervention will result in: - higher observed sensitivity and more positive attitudes towards sensitive caregiving in professional caregivers - lower cortisol levels, higher wellbeing and more attachment security in infants - less separation…

Study of gut microbiota profile in children with propionic acidemia

NA

Study to describe the processing of ropivacaine in the body when injected in the knee for pain treatment in total knee replacement surgery

The objective of this study is to describe a pharmacokinetic profile of total and unbound plasma concentrations ropivacaine, when used for local infiltration analgesia in total knee arthroplasty

The NOICH Study.

The hypothesis is that 0.5 g/kg/wk of IvIG is as effective as 1.0 g/kg/wk, in the prevention of ICH in FNAIT.

Feasibility and Efficacy of dose adjusted Melphalan ¨C Prednisone ¨C Bortezomib (MPV) in elderly patients >= 75 years of age with newly diagnosed Multiple Myeloma; a non-randomised phase II study

This study aims to assess the feasibility of a dose-adjusted MPV scheme in patients >= 75 years of age and to assess the value of geriatric assessments to predict both feasibility and efficacy.

A pilot, open-label, multi-centre study to investigate the safety of Calf Intestinal Alkaline Phosphatase in patients with fulminant active ulcerative colitis refractory to steroid therapy.

Ulcerative colitis is characterized by abnormal activation of the colon epithelium, which is considered to be a central pathogenic mechanism. Activation of colon epithelium cells in UC is associated with an abnormal high expression of Toll-like…

Immediate implant placement in molar extraction sites; a 5-year prospective case series pilot study

not applicable