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Rationale: Accumulating evidence suggests that increased generation of leukotrienes (LT) by the 5-LO pathway may have direct actions on the vessel wall, particularly the adventitia, in the evolution of abdominal aortic aneurysm (AAA). Augmented…
The main aims of the PROHTECT trial are to find out whether the compliance rate of the cervical screening programme can be improved by offering a self-sampling method for collecting cervicovaginal cell material at home for HPV testing, and…
Plasmalogens can be synthesized out of batyl alcohol (naturally occuring alkylglycerol) in patients with the peroxisomal disorder rhizomelic chondrodypslasia punctata (RCDP), bypassing the peroxisomal steps in the pathway.
The aim of the current randomized clinical trial (RCT) is a cost-effectiveness analyses of a collaborative care approach compared to Care as Usual (CAU). The collaborative care approach is expected to be more effective and cost-effective than CAU.
Persons with serious mental illnesses who participated in the consumer-run course show higher scores on subjective measures of recovery after three and six months than waiting-list controls
B cells contribute to the development of cGVHD.
The prupose if this study is; to accesss the feasibility of treatment of rAAA with a bifurcated endograft with the magnetic wire system to speed up the contralateral gate access.
In this study is patients with chronic hepatitis C with a previous virological relapse or a virological non response to IFN or IFN/Ribavirin combination therapy, with a high induction dose of pegylated Interferon combined with Ribavirin and…
The principal aim of this research project is to establish the origin of increased echogenicity in the thalami and basal ganglia (ED/TDG), an ultrasonographic finding fequently encountered in very preterm infants. It is not known whether ED/TBG is a…
Early laparoscopic cholecystectomy after endoscopic sphincterotomy for combined cholecystodocholithiasis, leads to less conversions as compared to laparoscopic cholecystectomy 6-8 weeks after sphincterotomy, and thus reduces morbidity and hosptal…
Continuing sulfonylurea in patients without good glycaemic control and using insulin and metformin, will diminish insulin secretion of beta-cells less than discontinuing sulfonylurea in these patients.
In this study previously untreated patients with chronic hepatitis C will receive high induction dose of IFN combined with Ribavirin and Amantadine for 6 weeks. Subsequently IFN is replaced by Peg IFN combined with Ribavirin and Amantadine. The aim…
By applying self monitoring of glucose, patients with diabetes type 2 may cope more independently with their disease. Self monitoring can aid in diabetes control by giving the patient the ability to make appropriate day-to-day treatment choices in…
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MLN3897 is safe and improves signs and symptoms of rheumatoid arthritis.
In view of good pre-clinical and clinical results, it is thought that patients with renal cell cancer will benefit from BAY 43-9006 in a neoadjuvant setting.We anticipate a benefit with the treatment of BAY 43-9006 when there is a tumour reduction…
A single bolus EPO administered just before a primary PCI for a first acute myocardial infarction will increase left ventricular function after 4 months.
GH treatment improves height, weight, body composition, muscle strength, activity level, psychosocial development, psychomotor development in infants, metabolism and respiratory function versus no GH treatment in children with Prader Willi Syndrome.
The hypothesis underlying this study is that duplex guided foam sclerotherapy may be cost saving and is more acceptable for patients than ligation and stripping of the greater saphenous vein, because there is no need for anaesthesia and incisions…
We tested, in a randomized, double-blind, placebo-controlled trial, the effects of pregabalin on pain relief, tolerability, health status, and quality of life in patients with central neuropathic pain.