969 resultaten
Hypothesis 1: the Groningen ULR and the Provox®2 are the same in terms of the replacement method, the burden on the patient and the convenience of the replacement and of the resistance during phonation. Hypothesis 2: the Groningen ULR has a longer…
The open preperitoneal approach in inguinal hernia repair might have the benefit of a mesh in the preferred space without the disadvantages of an endoscopic procedure.
Fluoxetine has in animals and cell cultures neuroprotective properties. We test whether fluoxetine is able to reduce progression in patients with multiple sclerosis.
Implantation of aspheric IOL's results in higher visual performance than spheric IOL's.
Strategies involving shorter and milder ovarian stimulation protocols and single embryo transfer may allow for more IVF cycles in the same period of time, resulting in similar term live birth rate per treatment period despite a minor reduction in…
Type 2 diabetes is cause by progressive beta-cell dysfunction against a background of obesity and insulin resistance in susceptible individuals. Peroxisome proliferator-activated receptor (PPAR) gamma-mediated mechanisms are involved in the…
It is hypothised that a pain consult at the specialized pain clinic in combination with Patient Education Program is more effective in reducing average pain intensity compared to a pain consult alone. A pain consult at the specialized pain clinic is…
rt-PA administration by retinal branch vein way in CRVO patients improves final BCVA.
The aim of the study is to optimize therapy of migraine patients, according to the Dutch GP Guideline for headache and consequently reduce the use of triptans. The project will explore the costs and effects of a proactive approach of patients with…
Children born small for gestational age (SGA) might be at increased risk for developing hypertension, cardiovascular disease and diabetes mellitus type 2. It has been shown that those SGA children with relatively higher GH levels during an overnight…
Participation in supportgroups leads to an improvement in quality of life, social support, social network, self-efficacy and self-esteem.
We will investigate the relationship between S(+)-ketamine plasmaconcentrations and its analgesic effect to estimates the onset/offset times of ketamine and potency parameters for various analgesia tests. This will allow the safer administration of…
To determine the influence of oral medicinal cannabis on the pharmacokinetics of irinotecan and docetaxel and their respective metabolites in cancer patients.
Psychological factors (such as depression, anxiety and life-events) play a role in the onset and course of CRPS1.
Prednisone inhibits progression of joint damage in early RA-patients, even when intensive treatment, according to a strict computer-assisted protocol, is applied.
A single subconjunctival Celestone chronodose injection immediately following cataract extraction reduces the incidence op post-op ocular inflammation when compared with conventional post-op eye drops therapy. Post-op administration of eserine does…
Cinacalcet is able to control hypercalciemia due to hyperparathyreoidism after renal transplantation ergo avoiding surgical removal of parathyroidtissue without jeopardizing renal function or eliciting serious adverse events.
It is our hypothesis that MIS will lead to better recovery compared to traditional total hip surgery during the early postoperative period (3 months), and at least as good at 6 months postoperatively.
A stepped care program in primary care for patients with depressive and/or anxiety disorders is more effective than care as usual.
Primary Objective: Aim of the study is to investigate whether sulodexide treatment reverses damage of the systemic glycocalyx in patients with DM type II. The effect of sulodexide will be addressed in this prospective cross-over study measuring…