1258 resultaten
Fentanyl is a strong opioïd and is highly lipophilic. Fentanyl pharmacokinetics are characterised by large inter- and intrapatient differences, which may have serious consequences for the activity and toxicity profile of this drug. The use of…
Recent pre-clinical experiments demonstrated that sorafenib in Oatp1b2(-/-) mice had 8-fold increased sorafenib-glucuronide blood concentrations.OATP1B1 and 1B3 are highly expressed in the human liver and facilitate the hepatocellular uptake of…
A low peak E2 during COS is considered to be safer than a high peak E2 in women with breast cancer
Depressive symptoms are common in older persons, often associated with poor physical function and vitamin D deficiency (serum 25-hydroxyvitamin D < 50 nmol/l). Simple and cheap interventions to prevent depression are lacking. Vitamin D…
The amino acid bioavailability of the Test Product is equivalent to Comparator Product 1
We hypothesize that respiratory viruses are frequently unrecognized as the causative pathogen of respiratory failure in critically ill patients. The aim of this study is to asses the prevalence and burden of respiratory viral infections in acutely…
Renal artery denervation (RDN) on top of pulmonary vein isolation (PVI) will improve the success of ablative therapy for patients who have paroxysmal and/or persistent atrial fibrillation, with out of range hypertension (systolic >140 mmHg or…
The development of a dry powder inhaler (DPI) that suits the needs of Parkinson’s patients, based on their inspiratory capacities, is essential. In this study, we will investigate the applicability of dry powder inhalation in Parkinson’s patients,…
The overall goal of this study is to test if the analogue patient paradigm is a valid method to assess the effects of physician-patient communication. More specifically, in Phase I, we aim to test if viewing a role-played interview about a common…
The addition of a specific fibre mixture to a breakfast cereal will impact the blood glucose response.
Type 2 diabetes is a major threat to human health. Disruption of the circadian timing system is associated with metabolic changes. Disturbance of the daily light and dark rhythm could contribute to this phenomenon and effects metabolic pathways. We…
Since there are no consistent data about feeding strategies in adults with mucositis, we designed a research project to study which feeding strategy is preferable in patients with chemotherapy-induced mucositis.
Are a positive psychology and a self-management intervention, equally effective in increasing quality of life and decreasing psychological distress and pain disability, in chronic pain patients, in comparison to a waiting-list control group?…
A risk-factor guided approach is more effective than usual care when treating dizziness in older patients in general practice.
To test the hypothesis that observing the data and waveforms displayed on an respiratory function monitor during the provision of positive pressure ventilation to preterm infants at birth will increase the proportion of tidal volumes within a…
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Enrolment in the Social Fitness programme improves participants' performance and satisfaction with meanungful social activities, their quality of life, patients’ mobility, caregivers’ sense of competence and a decreases resource utilization.
The proposed study aims to investigate a novel peri-operative PK-guided dosing strategy, which is expected to reduce FVIII consumption and costs by minimally 25%. Moreover, the five participating hospitals will gain experience with PK-guided dosing…
Postoperative pain, further blood loss, onset of delirium and wound discharge are unfavorable factors that can prolong hospital time, delay mobilization and necessitate transfusion. Cryotherapy and pneumatic compression are suggested to minimize…
The hypothesis of this study is that phenolisation of the sinus tract vs. primary surgical excision in patients with a symptomatic sacrococcygeal pilonidal sinus disease reduces days unable to do normal activities with only a small increase in…