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The prevention of lower extremity physical activity injuries; a school-based randomised controlled trial in children aged 10-12 years.

The promotion of safe sports participation proves effective in a physical education setting, resulting in a reduction of lower extremity injuries in children.

Blood transfusions at home.

Blood transfusions at home instead of in the hospital are feasible, lead to higher quality of life of patients and are safe at no higher costs.

Effects of scalp cooling on pharmacokinetics of paclitaxel in women treated for advanced breast cancer

During the cooling by a cold cap, the scalp is cooled to 4oC for a long period of time (30 minutes prior to start and up to 45 minutes after the infusion of paclitaxel). This could be of influence on the body temperature. Pharmacokinetics and…

Force measurements during hip arthroscopy

NA

Early treatment of central serous retinopathy by photodynamic therapy. A randomized controlled trial.

Visual outcome in CSR patients is superior when treated by Photodynamic Therapy (PDT) compared to observation.

Analyzes of pathogen and host determinants in hospitalized patients with a laboratory confirmed infection caused by Staphylococcus aureus: the PATHOS Study.

To identify candidate antigens for the development of a prophylactic Staphylococcus aureus vaccine by studying expression profiles of host and pathogen determinants during natural infection.

Leiden-Alloimmunization-Likelihood (LAL)trial.

The use of by filtration-leukocyte reduced blood transfusions in patients undergoing cardiac surgery, will result in lower alloimmunization frequencies compared to using buffy-coat depleted blood transfusions. This has previously been shown in…

Is the use of bloodplatelets effective in the treatment of difficult fistulas related to the anal sfincter?

The use of platelets in addition to mucosa advancement flap in the treatment of complex peri-anal fistula will reduce the recurrence rate of these fistulas.

Reducing skinbreaking procedures in newborns

The percentage of successful PIV insertions at the first attempt in newborns will increase with the Veinviewer® and/or Astodia®, two vascular imaging devices

Tailored physical activity intervention for the over-fifties.

1. In the first intervention group, the % of subjects who meet the national physical activity guideline will significantly increase; 2. In the second intervention group the % of subjects who meet the national physical activity guideline will…

Effects of long-term treatment with modafinil on relapse and impulse control in alcohol dependence.

It is expected that modafinil improves cognitive functioning in abstinent alcohol dependent patients, increases time to first relapse and reduces relapse rates and relapse severity. In addition, it is expected that participants with different…

The SHAPE study.

We hypothesise that exercise may reduce risk of breast cancer, either directly or indirectly through a reduction in abdominal fat mass, by favouring the sex hormone profile and decreased insulin. Because the association between breast cancer and…

Comparison of the effectiveness of a behavioural graded activity program and manual therapy in patients with sub-acute neck pain.

N/A

Observational study;
An open-label, phase 2a imaging study to assess the utility off 99mTc-NC100692 injection in post-MI patients to predict risk of developing chronic heart failure.

The hypothesis of the present study is to demonstrate that detection of a particular pattern (e.g., persistent vs. non-persistent) of myocardial (alpha)V(beta)3/5 expression by scintigraphy imaging at 3 and 8 weeks after MI can be used to determine…

Evaluation of safety and efficacy of mitapivat sulfate in adult patients with sickle cell disease.

The overall objective of this study is to assess safety of AG-348 and provide proof of concept of the efficacy of the drug in SCD patients. Based on currently available data, we hypothesize that the benefits of treatment of sickle cell disease…

Active plus: implementation and evaluation of two tailored physical activity interventions among the over-fifties.

1. It is hypothesized that participation in the Active plus program contributes to an increase in physical activity behaviour among older adults; 2. Additionally receiving physical and social environmental information results in an extra increase…

Online treatment for older dizzy patients in general practice

Stand-alone internet-based Vestibular Rehabilitation (VR) and internet-based VR with physiotherapeutic support is more (cost-)effective than usual care when treating dizziness in older patients in general practice.

A Double-Blind, Double-Dummy, Randomized, Placebo-Controlled, 3-Period, Crossover Study to Investigate the Effects of Ethanol and L-000830982 on Essential Tremor.

1. The effect of a single oral dose of L-000830982 versus oral placebo and an intravenous infusion of ethanol versus placebo on tremor over a 8-hour period in men and women with essential tremor will be estimated; 2. The sensitivity and specificity…

Treatment of Complex Regional Pain Syndome type 1: a randomised, double-blind, placebo-controlled study with S(+)-ketamine.

S(+)-ketamine reduces pain in patients with Complex Regional Pain Syndome type 1 having symptoms shorter than 6 months and longer than 3 years.

Efficacy of happiness exercises

- How effective are the Acts of Kindness exercises with and without reflection compared to an active control condition and wait-list condition on mental well-being, flourishing, positive relations, gratitude, positive and negative emotions, optimism…