No registrations found.
ID
Source
Brief title
Health condition
Alpha-Thalassemia
Beta-Thalassemia
Iron deficiency
Hereditary hemochromatosis
Sponsors and support
Intervention
Outcome measures
Primary outcome
Red blood cell deformability
Secondary outcome
Investigating underlying pathophysiological mechanisms of RBCs in thalassemia and iron disorders. Correlating clinical data, morphology of RBCs, haematological parameters and iron status to red blood cell deformability.
Background summary
Alpha- and beta-thalassemias are hemoglobinopathies in which a defect in alpha or beta globin chain production causes ineffective erythropoiesis and hemolysis, resulting in a microcytic anemia. Iron deficiency causes no hemolysis but results in microcytic anemia as well. Iron overload causes oxidative damage to red blood cells(RBCs). Many patients with hemoglobinopathies have either iron overload or iron deficiency. Their deformability will thus be influenced by their hemoglobinopathy and/or iron status. To delineate these interactions we will investigate changes in deformability of different hemoglobinopathies and iron status by using the Laser optical rotational cell analyser (Lorca), a next generation ektacytometer.
Study objective
With the Lorrca which measures red blood cell deformability patients with thalassemia show a different profile than patients with iron deficiency.
Study design
1
Intervention
Not applicable
M.A.E. Rab
Heidelberglaan 100
Utrecht 3508 GA
The Netherlands
088-7559059
M.A.E. Rab
Heidelberglaan 100
Utrecht 3508 GA
The Netherlands
088-7559059
Inclusion criteria
1. > 18 years
2. No blood transfusion within the past 3 months
3. Have alpha-thalassemia trait, homozygous alpha thalassemia, Hemoglobin H disease or other very severe forms of alpha-thalassemia, beta-thalassemia intermedia, iron deficiency anemia or hereditary hemochromatosis
4. Be able to give informed consent
Exclusion criteria
1. Suffering from a serious condition
2. Fever at time of venepuncture
3. Inflammatory condition at time of venepuncture
4. Not able to give informed consent
5. Blood transfusion in past 3 months
6. Intra venous iron therapy in past 6 months
Design
Recruitment
Followed up by the following (possibly more current) registration
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| NTR-new | NL6016 |
| NTR-old | NTR6780 |
| CCMO | NL56731.041.16 |
| OMON | NL-OMON46020 |