Research with human participants

Overview of medical research in the Netherlands

Het effect van deoxycholzuur op insuline

No registrations found.

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Ethical review
Positive opinion
Status
Recruiting
Health condition type
-
Study type
Interventional

ID

NL-OMON24716

Source

Nationaal Trial Register

Brief title

DCA

Health condition

Diabetes mellitus type 2, Obesity
type 2 diabetes mellitus, Obesitas

Sponsors and support

Primary sponsor :
Academic Medical Center Amsterdam
Source(s) of monetary or material Support :
Diabetes Fonds

Intervention

Outcome measures

Primary outcome

postprandial insulin and bile acid concentrations in plasma

Secondary outcome

postprandial resting energy expenditure and glucose concentrations.

Study objective

Deoxycholic acid might augment the postprandial insulin response through stimulation of TGR5 on enteroendocrine cells and beta cells.

Study design

0, 15, 30, 45, 60, 75, 90, 120, 150, 180 and 240 minutes

Intervention

single administration of 750 mg deoxycholate

Public
Academic Medical Center (AMC)<br>
Department of Endocrinology & Metabolism, F5-162<br>
P.O. Box 22660
M.R. Soeters
Meibergdreef 9
Amsterdam 1100 DD
The Netherlands
+31 (0)20 5669111
m.r.soeters@amc.uva.nl
Scientific
Academic Medical Center (AMC)<br>
Department of Endocrinology & Metabolism, F5-162<br>
P.O. Box 22660
M.R. Soeters
Meibergdreef 9
Amsterdam 1100 DD
The Netherlands
+31 (0)20 5669111
m.r.soeters@amc.uva.nl

Inclusion criteria

healthy lean male age 18+

Exclusion criteria

medication use

history of gastrointestinal surgery or gallstones

metabolic disease

Design

Study type :
Interventional
Intervention model
:
Crossover
Allocation :
Non controlled trial
Masking :
Open (masking not used)
Control :
N/A , unknown

Recruitment

NL
Recruitment status
:
Recruiting
Start date (anticipated) :
Enrollment :
10
Type :
Anticipated

Positive opinion
Date :
Application type :
First submission

Followed up by the following (possibly more current) registration

ID: 45029
Bron: ToetsingOnline
Titel: Effects of deoxycholic acid supplementation on insulin: role for the transmembrane G coupled protein receptor TGR5

Other (possibly less up-to-date) registrations in this register

No registrations found.

In other registers

Register ID
NTR-new NL5697
NTR-old NTR5849
CCMO NL44479.018.13
OMON NL-OMON45029