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ID
Source
Brief title
Health condition
Protein digestion
Sponsors and support
Intervention
Outcome measures
Primary outcome
Post-prandial plasma amino acid concentrations
Secondary outcome
Peak post-prandial amino acid concentration, overall post-prandial glucose and insulin responses & hunger, desire to eat and fullness
Background summary
Protein intake is an essential stimulus for protein anabolism. Protein anabolism is modulated by plasma amino acid availability. Various aspects of the dietary protein matrix have been shown to impact the post-prandial amino acid response. However, it has not yet been investigated if ingestion of protein in a solid (bar) form results in different post-prandial amino acid responses when compared to a liquid (drink) form.
Study objective
We hypothesize that ingestion of a solid protein form results in a less rapid rise in circulating post-prandial plasma amino acids compared to a liquid protein form.
Study design
Blood samples will be taken before food intake and at timepoints 15, 30, 45, 60, 90, 120, 150, 180, 210 & 240 minutes after ingestion.
Intervention
- 20 gram milk protein drink (liquid)
- 20 gram milk protein bar (solid)
Inclusion criteria
- Females
- Aged between 18-35 years
- Healthy, recreationally active (exercise at least 1 per two weeks and maximum 4 days a week)
- 18.5 ≤ BMI ≤ 30 kg/m2
- No physical limitations (i.e. able to perform all activities associated with daily living in an independent manner).
Exclusion criteria
- Smoking
- Lactose intolerant or allergies to milk proteins
- Musculoskeletal disorders
- Metabolic disorders
- Use of any medications known to affect protein metabolism (i.e. corticosteroids, nonsteroidal
anti-inflammatories, or prescribed acne medications).
- Chronic use of gastric acid suppressing medication or anti-coagulants
- Unstable weight over the last three months
- Diagnosed GI tract disorders or diseases
- Blood donation in the past 2 months
- Pregnant
- Third generation oral contraceptives
Design
Recruitment
IPD sharing statement
Followed up by the following (possibly more current) registration
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| NTR-new | NL9694 |
| CCMO | NL77723.068.21 |
| OMON | NL-OMON51160 |