Primary objective of this study is to investigate the possible correlation between non-invasive strain(rate) measurements with speckle tracking in the left atrium and invasive voltage measurements in the left atrium. Secondary abjectives are to…
ID
Source
Brief title
Condition
- Cardiac arrhythmias
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Correlation between left atrial strain and percentage LA low voltage points
Correlation between left atrial strain rate and percentage LA low voltage
points
Secondary outcome
Recurrence of atrial fibrillation within 12 months defined as registration of
atrial fibrillation on ECG or episode lasting >30 seconds on Holter/Vitaphone
recording (With blanking period of 3 months).
Correlation between left atrial strain and regional left atrial voltage.
Correlation between left atrial strain rate and regional left atrial voltage.
Correlation between serum uric acid and percentage LA low voltage points
Correlation between C-terminal telopeptide van collagen type-I (CITP) and
percentage LA low voltage points
Predictive value of combined left atrial strain/strain rate and mean LA voltage
for recurrent atrial fibrillation after catheter ablation.
Predictive value of left atrial strain/strain rate for recurrent atrial
fibrillation after catheter ablation.
Predictive value of mean LA voltage for recurrent atrial fibrillation after
catheter ablation.
Quality of life before and after PVI measured with SF-12 questionnaire
Background summary
Atrial fibrillation(AF) is a chronic progressive disease in which changes occur
in structure and function of the left atrium (LA). Structural remodeling is
characterized by LA enlargement and interstitial fibrosis, both being
predictors of recurrence of AF after pulmonary vein isolation. Despite
improvements in technical possibilities there is still a high failure rate of
non-farmacological treatment of atrial fibrillation, therefore non-invasive
assessment of structural changes by means of speckle tracking in the left
atrium could lead to better patient selection. We hypothesized that there
should be an relationship between LA structural remodeling assessed by invasive
voltage mapping in the left atrium and LA functional remodeling assessed by
strain and strain rate imaging in patients with AF.
Study objective
Primary objective of this study is to investigate the possible correlation
between non-invasive strain(rate) measurements with speckle tracking in the
left atrium and invasive voltage measurements in the left atrium. Secondary
abjectives are to assess whether correlation exists between regional voltage in
the left atrium and strain/strain rate measurements; laboratory values and
voltage measurements, recurrence rate, quality of life bofore and after
p[rocedure and predictive value of strain/strain rate measurements and voltage
measurements for recurrent atrial fibrillation after catheter ablation.
Study design
Single centre correlation study
Study burden and risks
Echocardiographic measurements are non-invasive of nature, additional burden
consists of extended measurements during routine echocardiography during
several minutes.
Construction of a voltage map is a safe procedure when performed by an
experienced operator. this will add 10 minutes to procedure time, which is
acceptable considering total procedure time of approximately 2 tot 3 hours.
Additional laboratory assessments pose no additional burden or risks.
Koningsplein 1
Enschede 7512 KZ
NL
Koningsplein 1
Enschede 7512 KZ
NL
Listed location countries
Age
Inclusion criteria
Patients > 18 years with paroxysmal atrial fibrillation referred for possible catheter ablation
Exclusion criteria
Unable to provide written informed consent
Unable to undergo echocardiographic evaluation
Previous PVI or MAZE procedure.
Emphysema
Pregnancy
Pacemaker or ICD
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
In other registers
| Register | ID |
|---|---|
| CCMO | NL51350.044.15 |
| Other | Volgt |