78 results
This study concerns research into the applicability and effectiveness of CBM-I training through an app on the mobile phone. The research is done in adolescents (12-18 years) treated at the Bascule clinic for OCD. The training will take place during…
To evaluate the effects of long-term intranasal oxytocin on social behaviour in children with PWS and to compare the effects of different doses and frequencies of oxytocin administration
In a series of randomized control trials (RCTs) the following hypothesis will be tested: Intranasal administration of oxytocin and vasopressin affect neural and behavioral responses to infant signals and threat to the infant.* Oxytocin and…
Primary objective:To show that addition of dead space to low-pressure nCPAP (which is usually not effective but can be relatively well tolerated) makes the therapy effective and diminishes the apnea hypopnea index with >10/hour in patients…
To determine the prevalence and severity of ASA-related allergic reaction in SM patients.
To test whether a short FD protocol can be used to test whether effects of light on alertness, sleep, metabolism and temperature are under circadian control.
The primary objective of this study is to assess the efficacy of Ecopipam to reduce self-injurious behaviors (SIB) in adults and children with Lesch-Nyhan Disease (LND) in an outpatient setting. The secondary objectives of this study are to assess…
Primary Objective:The primary objective in the current trial is to use graph theory to examine how the organization of the functional brain network may be altered by the administration of methylphenidate. The main question we intend to answer in…
To compare the blood pressure lowering effect of thiazides against calcium channel blockers in CNI-induced hypertension.
To study the influence of systemic blood flow and mean arterial pressure on cerebral blood flow in patients undergoing on-pump cardiac surgery.
The aim of the study is to investigate the effects on time trial / cycle test performance after ingestion of Snelle Jelle 'kruidkoek' and water, banana and water, or only water.
This study aims to determine to which degree the offered help - according to our treatment program - for familymembers and partners of murdered persons helps to treat complicated grief and PTSD (Murphy, 2006, Shear et al 2006) and to gain insight…
We will identify factors that interfere with the beneficial effects of exercise on the vasculature in T2DM.
In this study the effect of SAS and the treatment with CPAP on cognitive functioning, fatigue and mood in stroke patients will be investigated. The main research questions are: 1) Is there a relationship between (the severity of) SAS and cognitive…
At this time, iontophoretic administration of S(+)-ketamine is a already in use as a treatment of peripheral neuropathic pain in several pain clinics In the Netherlands (including the pain clinic at the Medical Center in Alkmaar). Although this…
Primary Objective: To determine oral, gastric and duodenal lipid degradation of fat preloads .Secondary Objectives: To study how the oro-gastro-intestinal digestion of these fat preloads relates to: - Colloidal stability. For this we will monitor…
Investigate the effects of levocetirizine, diphenhydramine and placebo on cognitive and psychomotor functioning during controlled simulated diving in a recompression chamber in professional navy divers at 10 mt (2 bar) and 30 mt (4 bar).
Primary objective: to compare changes in endothelial function in patients with obesity related hypertension after 8 weeks of treatment with aliskiren, moxonidine and HCTZ.Secondary objectives: to compare changes in the following parameters in…
To establish if and how the endocannabinoid system is involved in ADHD and related symptoms. This will be investigated by assessing the acute effects of a cannabinoid agonist (THC) on brain function related to ADHD and ADHD symptoms.
Based on the positive effects of Celecoxib on ultrafiltration and peritoneal injury during PD in rats, we would like to propose a pilot study using Celecoxib in PD-patients. In this pilot study we will investigate whether the Cox2 inhibitor…