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A multicenter study evaluating the diagnostic value for vascular abnormalities of High Definition Bronchoscopy when combined with i-scan Imaging Technology compared to High Defintion Bronchoscopy alone

Primary objective:Determing the positive predictive value and diagnostic yield of HD+ i-scan bronchoscopy for vascular pattern detection .Secondary objectives:1. To investigate the correlation of vascular abnormalities with histology2. To…

High Definition bronchoscopy, an exploratory study of diagnostic value in comparison to standard white light bronchoscopy and autofluorescence bronchoscopy

(1) Investigate diagnostic performance (sensitivity) of HD bronchoscopy, with or without surface enhancement or tone enhancement in comparison to standard WLB for detecting abnormalities of the tracheobronchial tree. Furthermore we aim to…

LUME-Lung 3. A Phase I/II study of continuous oral treatment with BIBF 1120 added to standard gemcitabine/cisplatin therapy in first line NSCLC patients with squamous cell histology.

Run-in phase I: To confirm the safety and tolerability of BIBF 1120 up to a dose level of 200 mg b.i.d added to a standard dose of cisplatin/gemcitabine in first line NSCLC patients with squamous cell histology. Pharmacokinetics of BIBF 1120 and…

Demonstrating Pemetrexed induced Thymidylate Synthase inhibition in non-small cell lung cancer in vivo: a pilot study.

The aim of the present study is to investigate whether a 4 hr time lapse between the first dose of pemetrexed in NSCLC is associated with increased FLT uptake, in responding patients.

Open-label, randomised, multi-center study investigating Cetuximab, in combination with concurrent chemo- / radiotherapy in locally advanced non-small cell lung carcinoma

The aim of the study is to assess the feasibility of combined treatment of Cisplatin, Cetuximab and concurrent RT and to get insight in the clinical efficacy (for study schedule, see flow chart 1). The first phase of the study will mainly focus on…

Respiratory signal driven breathing instructions to improve spatial alignment between respiratory gated PET and breath-hold CT

Is it possible to increase the spatial match between PET and CT imaging with the use of a respiratory instructed breath hold CT?

Netherlands Quality of Life and Biomedical Cohort Studies_Head and Neck Cancer

The primary objective is 1) to describe the long-term course of QoL in HNC patients and their informal caregivers and to identify cancer-related, personal, genetic, biological, psychobehavioural, physical, lifestyle-related, and social determinants…

A phase III, multicenter, randomized, open-label study of oral LDK378 versus standard chemotherapy in adult patients with ALK-rearranged (ALK-positive) advanced non-small cell lung cancer who have been treated previously with chemotherapy (platinum doublet) and crizotinib

The primary objective is to compare the antitumor activity of LDK378 versus reference chemotherapy.The key secondary objective is to compare Overall Survival (OS) in patients treated with LDK378 versus reference chemotherapy (pemetrexed or docetaxel…

The Galvanize Therapeutics Early Stage, Non-Small Cell Lung Cancer, Treat and Resect Study

To evaluate the safety and initial feasibility of PEF treatment of NSCLC tumors prior to surgical resection.

A Two-cohort, Phase 2 Study of FL-101 as Neoadjuvant Therapy in Patients with Surgically Resectable Non-Small Cell Lung Cancer

Primary Objective:To evaluate the safety and tolerability of FL-101 as monotherapy and in combination with nivolumabTimepoint of evaluation of primary objective: From first dose to 3 months after surgerySecondary Efficacy Objectives1. Cohort 1: To…

A phase III multicenter, randomized study of oral LDK378 versus standard chemotherapy in previously untreated adult patients with ALK rearranged (ALK-positive), stage IIIB or IV, non-squamous non-small cell lung cancer

The primary objective is to compare the antitumor activity of LDK378 versus reference chemotherapy

A Phase 2 Randomized Study of Relatlimab plus Nivolumab in
Combination with Chemotherapy vs. Nivolumab in Combination with Chemotherapy as First Line Treatment for Participants with Stage IV or Recurrent Non-small Cell Lung Cancer (NSCLC)

This study has been transitioned to CTIS with ID 2023-508372-10-00 check the CTIS register for the current data. Part 1: dose safety confirmationPrimary: To evaluate the proportion of participants with TRAEs leading to discontinuation within 12…

Individualized pemetrexed dosing in patients with non-small cell lung cancer or mesothelioma based on renal function to improve treatment response - The IMPROVE-I, -II and -III studies -

The overall main objective is to develop a safe and effective individualized dosing regimen for pemetrexed.

A randomized, phase 3 trial with anti-PD-1 monoclonal antibody pembrolizumab (MK-3475) versus placebo for patients with early stage NSCLC after resection and completion of standard adjuvant therapy (PEARLS)

This study has been transitioned to CTIS with ID 2023-509137-39-00 check the CTIS register for the current data. Primary/dualco-primary. To prospectively investigate whether adjuvant treatment with pembrolizumab after completion of radical surgery (…

A Two-Cohort Phase 2 Study of FL-101 as Neoadjuvant Therapy in Patients with Surgically Resectable Non-Small Cell Lung Cancer

Primary Objective:To evaluate the safety and tolerability of FL-101 as monotherapy.Timepoint of evaluation of primary objective: From first dose to 3 months after surgerySecondary Efficacy Objectives1. Cohort 1: To evaluate the activity of FL-101…

Multicenter pilot study to determine the feasibility of a multimodal prehabilitation program in patients with non-small cell lung cancer undergoing anatomical lung resection

To determine whether the multimodal prehabilitation program (without extending the time from MDT meeting to operation beyond the DLCA-S norm of 3 weeks) for patients with NSCLC undergoing anatomical lung resection in MMC and ASz:1. is feasible 2.…

MicroRNA profiles in blood and urine in lung cancer: a pilot study

The primary objective of this study is to compare the profile of MicroRNA*s in the urine and blood of lung cancer patients with the profile of MicroRNA*s in the urine and blood of non-lung cancer patients with similar symptoms and with that of…

Characterization of Methylation Patterns in Lung Cancer (Lung-RND-001)

• Characterization of methylation patterns in blood samples and finding of methylation patterns that are unique to lung cancer.• Development of a molecular test for early diagnosis of lung cancer from a blood sample that will be more sensitive and…

Are circulating hematopoietic stem and progenitor cells a potential biomarker for therapy response and disease progression in patients with squamous cell carcinoma of the head and neck?

We hypothesize that the cytokines secreted by HNSCC may perturb the hematopoiesis in patients. We wonder whether this perturbation can be restored after local treatment of the tumor.Primary objective: In this pilot study, we aim to prospectively…