24 results
1). To compare temporal fluctuations of lung function and inflammatory biomarkers in blood, nasal lavage, exhaled air and urine between patients with asthma and controls.2). To investigate the change in variations of these biomarkers upon…
With the aim to restrict inappropriate FFP transfusions to critically ill patients, a randomized clinical trial will be conducted in a subgoup of ICU patients undergoing an invasive procedure. The objective is to assess the effectiveness and costs…
We postulate that exhaled molecular profiling obtained from *breathprints* by electronic nose:1. Will discriminate eosinophilic asthma from non-eosinophilic asthma2. Is associated with individual biomarkers and specific proteomic profiles in induced…
Our hypothesis is that antibodies of COPD patients contribute to inflammatory processes leading to cell death, and that the level of cytotoxicity differs between COPD patients and healthy volunteers. The prime aim is to detect differences in…
Part I of the study: I) to determine if one or a batch of aging marker(s) is/are associated with the presence of objectively diagnosed COPD related co-morbidity (muscle wasting, osteoporosis, cardiovascular risk, glucose intolerance, renal failure,…
The objective of this study is to test our hypothesis:Hypothesis - We postulate that the development of asthma in preschool children can be captured during the first 2 years of life by a minimally invasive *fingerprint* based on the combination of:…
Primary Objective: 1) To investigate if the intestinal permeability acutely increases during physical activity (submaximal cycle ergometry or ADL test) in clinically stable patients with moderate to severe COPD; 2) To investigate if the intestinal…
Besides more basic research into which RNA-binding proteins and microRNAs regulate the expression of inflammatory mediators in airway epithelial cells, we will also assess these proteins and microRNAs in airway epithelial cells from patients with…
Primary endpoint:Measuring lymphocyte response in patients with suspected pulmonary bird fanciers lung by ELISPOT technique.
We hypothesize that expiratory VOC-analysis by electronic nose is capable of:1. Discriminating between asymptomatic infants and infants with respiratory wheeze.2. Discriminating between parent-reported and doctors-confirmed wheezy infants.The aim of…
which particles can be found in induced sputum of construction workers? What is the composition, size and concentration of quartz particles measured in sputum of the different exposure groups?
Research questions:Is the chronic inflammatory response in COPD caused by a dysfunction of regulatory T cells?1. Is the number of Tregs decreased in COPD?2. Is the function of the Tregs impaired in COPD? And if so,a. Is this associated with a…
To evaluate the effect and feasability of a short support program for patients with IPF and their partners. The secondary objective is to explore if hair cortisol, as a measure of chronic stress, is a feasible biomarker for Quality of Life in IPF.
Our primary objective is to identify which intrinsic defect in Tregs is crucial for sarcoidosis pathology. To this end we will examine the genetic and functional properties of Tregs in the peripheral blood and at the site of disease, i.e. the lung…
The primary objective is to compare the incidence of patient-ventilator-asynchrony during paediatric mechanical ventilation using ventilator waveforms with PVA detected by using the ventilator waveforms in combination with diaphragm and intercostal…
The main objective of our Center for Translational Pediatric Pulmonology (CTPP) is to establish models of bronchial epithelial function in children, by (1) epithelial organoid cultures derived from bronchial epithelial cells; (2) bronchial brushings…
Primary Objective: To identify the variability in the circulation of the number of patrolling monocytes and their expression of CX3CR1 obtained from adult ZZ-AATD patients compared to spouse controls.Secondary Objective(s): (1) To identify if low…
To compare young and old COPD immunologically, physiologically, risk factors, patient behaviour and quality of life.
Primary Objective: The primary objective of this study is to assess lung volume measured by EIT and minute ventilation measured by the ventilator during CMV and FCV at the ICU. This will allow for an adequate powercalculation for future studies.…
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