80 results
The primary aim is to investigate whether six weeks augmentation with clonidine of the antipsychotic treatment will reduce positive and negative symptomatology of treatment resistant schizophrenia patients. Important secondary goals of this project…
The primary aim of this study is to examine whether TAU plus MBT-P has a more positive effect on social functioning than TAU only.Secondly it will be examined whether this potential therapeutic effect is driven by an increase in social cognitive…
Primary Objective: The aim of this study is to determine the time to all-cause discontinuation of penfluridol (acemap; oral long acting neuroleptic) as compared to second-generation oral neuroleptics (olanzapine, risperidone) using an open label…
Primary objectives:* To explore the comparative bioavailability between 12.5 mg of Risperdal® Consta® prepared from a 25 mg dose strength of Risperdal® Consta® EU-sourced, and 12.5 mg of Risperdal® Consta® prepared from a 12.5 mg dose strength…
Primary objective is to compare all cause discontinuation rates in patients with schizophrenia randomized to either one of the two depot medications (aripiprazole depot or paliperidone palmitate) with patients randomized to either one of the two…
In Part 1, a single dose will be administered of RO6889450 or placebo (same formulation but then without the active ingredient RO6889450). The purpose of Part 1 is to investigate how safe RO6889450 is and how well RO6889450 is tolerated. Part 1 will…
Primary:to evaluate the safety and tolerability of EVP-6308 after single and multiple ascending dose administration in healthy subjects.Secondary:to determine the pharmacokinetics of EVP-6308 and select metabolites following single and multiple oral…
The objective of the study is to determine if virtual reality exposure therapy (VRET) is an effective treatment for enhancing social participation in people with a psychotic disorder or generalized social anxiety disorder. The primary objective is…
To establish the effect of an adapted form of MCT (MCT-a) on paranoid ideation and cognitive insight in patients with recent onset psychotic symptoms.
Primary objective of the study is to investigate whether Behavioral Activation for Negative Symptoms (BANS) improves negative symptoms. Secondary objective is to investigate whether effects of BANS on negative symptoms is mediated or moderated by…
The purpose of the study is optimising current treatments in schizophrenia and explore novel therapeutic options for schizophrenia. The study intends to both address basic, but so far unanswered, questions in the treatment of schizophrenia and…
To evaluate the applicability and (cost-) effectiveness of a shortened, partly group based, Cognitive Behavioural Therapy (CBTsa) focussing on social activation in patients with recent onset schizophrenia.
The study will be performed in 2 parts, Parts 1 and 2. The volunteers can only participate in one of the two parts of this study. The purpose of Part 1 of the study is to investigate to what extent RO6806127 is tolerated. It will also be…
Main objective Part 1: To assess the safety and tolerability of RO6799477 after multiple ascending oral doses in healthy volunteers.Part 2: To assess the safety and tolerability of RO6799477 after multiple oral doses in patients with type 2 diabetes…
The objective of this study is to see wether the use of eye movement (EMDR) reduces the emotionality en vividness of imagery (mental images) above 'recall only'. This is a first study which may be the predecessor of a larger study, in…
To examine the effect of L-dopa addition to optimal D2-blocking antipsychotic treatment on positive symptoms, negative symptoms, cognitive symptoms and extrapyramidal symptoms in schizophrenia.
The primary goal of this study is to assess how M4M affects acceptance of antipsychotic depot medication, during the intervention and after terminating the intervention.
The following hypotheses are tested in the current study: 1) Metacognitive training is more effective than the standard treatment (TAU) for changing paranoid thinking in patients with psychotic disorders. Subhypothesis: 1a) Metacognitive training is…
This proposal entails a proof-of-concept study into the neuropsychological effects of memantine augmentation in a random cross-over comparison to placebo, as add-on treatment to ongoing clozapine in severely mentally ill (SMI) patients with…
- to examine the safety and tolerability of the research medication- to examine how the research medication is absorbed, broken down and excreted by the body.