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Is endometrial withdrawal bleeding necessary prior to ovulation induction with clomiphene citrate?;A randomized controlled trial and feasibility study

To evaluate the effects of withholding progesterone-induced endometrial withdrawal bleeding before ovulation induction on the time to pregnancy and the ongoing pregnancy rate.

The effect of uterine bathing on implantation in endometriosis patients undergoing IVF/ICSI: a randomized controlled pilot trial

To evaluate the effect of uterine bathing in improving the results of IVF/ICSI treatment in patients with endometriosis ASRM stage I-IV.

Costs and effects of a structured lifestyle program in overweight and obese subfertile couples to prevent unnecessary treatment and improve reproductive outcome.;Titel follow-up:
- WOMB women - Preconception lifestyle intervention: does it affect long term female health?
- WOMB kids - Preconception lifestyle intervention: does it affect offspring*s health?

In view of this lack of evidence and strong practice variation we propose a randomized clinical trial in overweight and obese subfertile women, in which we compare the costs and effects of a six months structured lifestyle program, aimed at weight…

Erasmus MC Care Innovation for a healthy pregnancy. Efficacy of "Smarter Pregnant", an interactive food and lifestyle program on the mobile phone.

Investigate whether the "Smarter Pregnant" intervention in comparison with four screenings with food- and lifestyle advising leads to an improvement in unhealthy food habits (vegetables, fruit, folic acid use) after 24 weeks intervention,…

A Phase 1, Randomized, Blinded, Placebo-Controlled, Dose-Ranging Study of MVT-602 in Healthy Premenopausal Women

PrimarySafety and tolerability of MVT-602 following single dose subcutaneous administration in healthy premenopausal womenSecondaryPharmacokinetics (PK) and pharmacodynamics (PD) of MVT-602 following single dose subcutaneous administration

The effect of pH on human embryo development

To study the in vitro development of embryos in a pH that better resembles the pH of the uterus.

A single blind, randomized, cross-over placebo controlled dose finding study to investigate the pharmacokinetic profile of 3 doses of sublingual testosterone solution and their effect on physiological and subjective arousal in healthy, sexually functional premenopausal women.

Primary objectives:To establish the lowest effective dose using physiological and subjective measures of sexual arousal.To evaluate and compare the pharmacokinetics of testosterone and its metabolites following administration of three (3) doses (0.…

Cost-effectiveness of IUI, IVF and ICSI for male subfertility. The MAle Subfertility Therapy Effectiveness Rcts (MASTER).

In one third of subfertile couples male subfertility is diagnosed. Current treatments for male subfertility, IUI, IVF and ICSI, have,despite their widespread use, not been compared on their cost-effectiveness. The primary aim of this project is to…

THL study: A multicenter trial comparing the cost-effectiveness of transvaginal hydrolaparoscopy and hysterosalpingography in the work-up for subfertility.

Objectives: The purpose of this study is to assess the costs and effects of THL compared to HSG in a large randomized controlled trial.

A phase I, mono-center, randomized, placebo and comparator controlled, single blind, rising dose, clinical study to determine single dose pharmacokinetics, pharmacodynamics, safety and tolerability of four doses of FSH-GEX* according to adaptive design (25, 75, 150 and 300 IU) administered subcutaneously in healthy pituitary-suppressed female volunteers

- To assess the safety and (local) tolerability of test compound following single rising dose administration by subcutaneous injection- To determine FSH pharmacokinetic parameters including Cmax and AUC0-last of test compound following single rising…

A rising multiple dose study to investigate the safety, tolerability, pharmacokinetics and pharmacodynamics of orally administered SCH 900389 in healthy females (P07036)

To investigate the safety and tolerability of the test compoundTo study how the test compound is absorbed, broken-down and excreted by the bodyTo study the effect of the test compound on the functioning of the body, particularly the ovaries and sex…

A double blind, randomized, cross-over placebo controlled study to investigate the efficacy of sublingual testosterone solution on physiological and subjective arousal in healthy, sexually dysfunctional premenopausal women.

Primary objectives:To confirm the lack of effect of 0.5 mg sublingual testosterone on physiological and subjective measures of sexual arousal in women with HSDD. Secondary objective:To confirm the lack of effect of 0.5 mg sublingual testosterone on…

Patient-controlled remifentanil analgesia (PCA) during oocyte retrieval for IVF/ICSI procedures

The main objective of this open-label, randomized clinical trial is to asses whether patient-controlled analgesia with remifentanil is more efficious and equally safe as pethidine as analgesic strategy during ultrasound-guided transvaginal oocyte…

A phase I, mono-center, placebo and comparator controlled, single-blind, randomized, parallel group, clinical study to determine multiple dose safety, tolerability, pharmacokinetics, and pharmacodynamics of FSH-GEX* administered subcutaneously in healthy pituitary-suppressed female volunteers

- To assess the safety and tolerability of FSH-GEX* following multiple dose administration by subcutaneous injection- To determine the pharmacokinetic profile of FSH-GEX* following multiple dose administration by subcutaneous injection- To assess…

HSG versus HyFoSy: is there a difference in VAS-painscores between these two tubal patency tests?

To determine wether a HyFoSy is a less painful procedure compared to a HSG examination for tubal patency testing

Cryo-thawed embryo transfer: natural versus artificial cycle. A non inferiority trial.

To compare live birth rates among patients receiving cryo thawed embryo transfer after endometrial preparation with estrogen/progesterone substitution and patients receiving cryo thawed embryo transfer in a natural cycle.

PK/PD trial with different dose regimens of Cyclogest® in comparison to Crinone® and placebo in healthy female subjects

To investigate the effect of various dose regimens of Cyclogest® on secretory transformation of the endometrium in comparison to Crinone® and placeboTo investigate single and multiple dose pharmacokinetics of Cyclogest®To investigate safety and…

Assessing the course of psychological emotions and endocrine stress response from the start of the ovarian stimulated period up to the first pregnancy test result in a randomized clinical trial comparing two fertility treatments.

To evaluate the course of psychological emotions, from the active treatment period until the first pregnancy test result, in IVF patients participating in a randomized controlled trial comparing two different IVF treatments (ENDO-RECEPT).

Prospective, multicenter, randomized controlled trial towards identifying the optimal Cetrotide treatment protocol

To demonstrate whether an early fixed start antagonist protocol improves the live birth rate compared with a late fixed start antagonist protocol.

A single-center non-blinded randomized controlled trial on the effect of ovarian hyperstimulation on endometrial receptivity

To compare the cumulative ongoing pregnancy rate after transfer of frozen/thawed embryos in a cycle without ovarian hyperstimulation with transfer of fresh embryos in a cycle with ovarian hyperstimulation.