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Salivary cortisol response and VO2max during standardized excercise test in children with and without asthma

To determine whether the attenuated salivary cortisol response in children with asthma can be explained by the maintenance use of inhaled cortiocosteroids, the chronic inflammatory disease, or the attenuated exercise capacity.

Is antenatal prednisone exposure associated with chronically elevated cortisol levels in children?

The aim of this study is to determine whether children between 5-17 years born to women with an autoimmune disorder and prednisone use during pregnancy have chronically elevated cortisol levels compared to children born to women with an autoimmune…

Salivary, plasma metanephrines and anxiety levels in pheochromocytomas

To determine the sensitivity and specificity of salivary metanephrines and in patients with PCC/sPGL.

Primary aldosteronism in general practice: organ damage, epidemiology and treatment

Objectives: Part 1) To assess the prevalence of PA in general practice (part 1 of this study);Part 2) To describe differences of cardiorenovascular damage in newly diagnosed hypertensive patients with versus without PA (part 2 of this study);Part 3…

Recovery of circadian rhythm of the hypothalamic-pituitary-adrenal axis during glucocorticoid tapering in ANCA-associated vasculitis, a pilot study

The primary aim of this study is to investigate the recovery of the circadian rhythm of the hypothalamic-pituitary-adrenal axis during a glucocorticoid tapering regime. Secondary objectives include the effect of a tapering regime on melatonin rhythm…

Value of multimodality image registration of cone-beam CT and CT in adrenal vein sampling procedures in increasing success rate

To determine the value of multimodality image registration of cone-beam CT (CBCT) and CT in increasing the success rate of adrenal vein sampling procedure compared to procedures without CBCT guidance.

A multicenter prospective study of biochemical profiles of monoamine-producing tumors: utility
for diagnosis and determinants of clinical presentation. (The PMT study)

Primary objective:to identify new and improved disease biomarkers and establish the biochemical and molecular basis for variations in the clinical presentation of the different groups of tumors.Secondary objectives:• compare the diagnostic utility…

Efficacy of adjuvant mitotane treatment in prolonging recurrence -free survival in -patients with adrenocortical carcinoma at low-intermediate risk of recurrence

Primary objectiveTo compare the efficacy of adjuvant mitotane treatment vs observational follow-up only in prolonging recurrence free survival (RFS) in patients with ACC after complete resection and low-intermediate risk for disease recurrence.…

Towards cost-effective diagnostic management of patients with primary aldosteronism: adrenal vein sampling or CT-scan?

Here we propose to perform a prospective, randomized, multicenter study that compares effectiveness of AVS with effectiveness of CT-scanning for the diagnosis of PA subtype. There is no criterion standard for accuracy of the diagnosis of PA-subtype…

Pilot-study: Dexamethasone and function of the HPA axis in children after treatment for Acute Lymphoblastic Leukemia; Relation to sleep

The objectives of this pilot study are to explore differences in sleep and fatigue, and the relation with the function of the HPA axis, between survivors of childhood ALL and healthy controls.

Quality of life, cognitive functioning, psychopathology, and personality traits in patients with primary adrenal insufficiency

To answer the following research questions:How is quality of life in patients with adrenal insufficiency?How is cognitive functioning in patients with adrenal insufficiency?Is there a difference in cognitive functioning between patients who did/did…

Brown adipose tissue activation on PET-CT in patients diagnosed with pheochromocytomas or Cushings syndrome.

Study the mechanisms of BAT activity and the effects of BAT acitivity on energy homeostasis.

DREAMS II Study; HPA axis function and sympathetic nervous system activity in survivors of childhood acute lymphoblastic leukemia

To study HPA axis regulation and sympathetic nervous system activity in survivors of childhood ALL during relaxation and during stress.

Immunological and adrenal function in children with CHARGE syndrome

Our primary objectives are:- to estimate the prevalence of central adrenal insufficiency , defined as a plasma cortisol response <500 nmol/l in the low-dose ACTH test (see paragraph 8.3.5 of the protocol). - to describe immune dysfunction, i.…

Consequences of suboptimal glucocorticoid replacement therapy in Addison*s disease; The metabolic syndrome and quality of life.

Assess the prevalence of the metabolic syndrome and quality of life in patients with Addison*s disease treated with low dose GRT. Study the relation between GRT, QoL and glucocorticoid receptor polymorphisms

Normal values of salivary androstenedione and 17 hydroxy progesterone in children

To investigate the correlation between androstenedion in saliva and serum in all patients that have a request for androstenedion in serum.To collect age related reference ranges for healthy children on three different time points.

Influence of a Catecholamine-Rich Diet on Plasma and Urine Free and Total Metanephrine, Normetanephrine and 3-Methoxytyramine Concentrations.

The aim of the present study is to assess the necessity of dietary restrictions before sampling for the biochemical diagnosis of pheochromocytoma. Therefore, the short-term influence of a catecholamine-rich diet on plasma free and total metanephrine…

Adrenal vein sampling as a tool to identify biomarkers that aid the diagnosis of adrenocortical carcinoma

To detect differences between ACC patients and controls without ACC, and between the diseased and healthy adrenal gland of ACC patients, in microRNA (miRNA), circulating cell-free tumor DNA (ctDNA), circulating tumor cells (CTCs), and steroid…

Optimizing timing of glucocorticoid treatment in children with congenital adrenal hyperplasia

To study the effects of 2 standard treatment timing strategies for glucocorticoid dosage on androgen concentration in CAH children: a. highest dosage in the morning, b. highest dosage in the evening.

A Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Safety and Efficacy of Crinecerfont (NBI-74788) in Adult Subjects with Classic Congenital Adrenal Hyperplasia, Followed by Open-Label Treatment (CAHTALYST)

The purpose of this study is to see if Crinecerfont is effective in reducing daily glucocorticoid dosage while maintaining adrenal androgen control.The purpose of the study is also to see if Crinecerfont is effective in reducing adrenal steroid…